475856 Sigma-AldrichMitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem
The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.
More>> The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one, Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor
Empfohlene Produkte
Übersicht
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 338967-87-6 | C₁₅H₁₀Cl₂N₂O₂S |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 475856-10MG |
|
Kst.-Ampulle | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC50 = 10 and 50 µM in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50 < 10 µM) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- (Cat. Nos. 569396 and 569397) as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release. |
| Catalogue Number | 475856 |
| Brand Family | Calbiochem® |
| Synonyms | 3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one, Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor |
| References | |
|---|---|
| References | Cassidy-Stone A., et al. 2008. Dev. Cell 14, 193. |
| Product Information | |
|---|---|
| CAS number | 338967-87-6 |
| Form | White solid |
| Hill Formula | C₁₅H₁₀Cl₂N₂O₂S |
| Chemical formula | C₁₅H₁₀Cl₂N₂O₂S |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥95% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Bestellnummer | GTIN |
| 475856-10MG | 07790788056377 |