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444295 MT1-MMP Inhibitor, NSC405020 - CAS 7497-07-6 - Calbiochem

Übersicht

Key Spec Table

CAS #Empirical Formula
7497-07-6C₁₂H₁₅Cl₂NO

Preis & Verfügbarkeit

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444295-25MG
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      Glasflasche 25 mg
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      Description
      OverviewA cell-permeable pentanylbenzamide compound that acts as an allosteric, reversible, and selective inhibitor of the collgenolytic activity of MT1-MMP. Does not affect the catalytic activity of cellular MT-1-MMP thus allows it to retain its ability to activate MMP-2. Selectively targets the hemopexin (PEX) domain of MT1-MMP, thereby repressing its pro-tumorigenic activity. Its binding to the PEX domain is dependent on Met-328, Arg-330, Asp-376, Met-422, and Ser-470 in the druggable pocket of the enzyme. Shown to block 184B5-MT cell migration on collagen-1 and repress MCF7-β3/MT tumor growth in xenografted mice (0.5 mg/kg, intratumoral).
      Catalogue Number444295
      Brand Family Calbiochem®
      Synonyms3,4-Dichloro-N-(pentan-2-yl)benzamide, 3,4-Dichloro-N-(1-methylbutyl)benzamide
      References
      ReferencesRemacle, A.G., et al. 2012. Cancer Res. 72, 2339.
      Product Information
      CAS number7497-07-6
      FormOff-white solid
      Hill FormulaC₁₂H₁₅Cl₂NO
      Chemical formulaC₁₂H₁₅Cl₂NO
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Bestellnummer GTIN
      444295-25MG 04055977186116