504173 Sigma-AldrichMAT2A Inhibitor II, FIDAS-5 - CAS 1391934-98-7 - Calbiochem
Empfohlene Produkte
Übersicht
| Replacement Information |
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 1391934-98-7 | C₁₅H₁₃ClFN |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 5041730001 |
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Glasflasche | 10 mg |
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| Description | |
|---|---|
| Overview | A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) analogue of FIDAS-3 (Cat. No. 681677) that competes against SAM for MAT2A binding and is >2-fold more potent than FIDAS-3 in inhibiting MAT2A-catalyzed SAM synthesis both in cell-free assays (IC50 = 2.1 µM) and in LS174T colorectal cancer (CRC) cultures (3 µM). FIDAS-5 at 3 µM is shown to completely inhibit the proliferation of LS174T for up to 7 d in vitro and effectively suppress HT29 CRC tumor expansion in mice in vivo (20 mg/kg/day p.o.). |
| Catalogue Number | 504173 |
| Brand Family | Calbiochem® |
| Synonyms | Methionine S-Adenosyltransferase 2A Inhibitor II, FIDAS5, (E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline |
| References | |
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| References | Zhang, W., et al. 2013. ACS Chem. Biol. 8, 796. |
| Product Information | |
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| CAS number | 1391934-98-7 |
| Form | Yellow semi-solid |
| Hill Formula | C₁₅H₁₃ClFN |
| Chemical formula | C₁₅H₁₃ClFN |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | MAT2A |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 5041730001 | 04055977263831 |
Documentation
MAT2A Inhibitor II, FIDAS-5 - CAS 1391934-98-7 - Calbiochem SDB
| Titel |
|---|
MAT2A Inhibitor II, FIDAS-5 - CAS 1391934-98-7 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 504173 |
Literatur
| Übersicht |
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| Zhang, W., et al. 2013. ACS Chem. Biol. 8, 796. |
Broschüre
| Titel |
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| New Products Flyer- Feb 2014 - Vol 1 |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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