435801 Sigma-AldrichLicofelone, Potassium Salt, Monohydrate - CAS 156897-06-2 - Calbiochem
Synonyme: 2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl, 2,3-dihydro-1H-pyrrolizine-5-yl)-acetic acid, ML3000, ML-3000, COX-1 Inhibitor V, FLAP Inhibitor II, mPGES-1 Inhibitor II
Empfohlene Produkte
Übersicht
Preis & Verfügbarkeit
Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
---|---|---|---|---|---|---|
435801-25MG |
|
Glasflasche | 25 mg |
|
— |
Description | |
---|---|
Overview | A cell-permeable, orally active arylpyrrolizine carboxylate that is structurally and pharmacologically similar to, but less potent than, MK-886 (Cat. No. 475889). Effectively suppresses cellular Cox pathway PGE2 production by inhibiting COX-1 and mPGES-1, but not COX-2 (IC50 = 0.8, 6, and >30 µM, respectively), and inhibits cellular 5-LO (5-Lypoxygenase; Cat. No. 437996) pathway activation (IC50 = 0.18 to 3.6 µM against ionophore-stimulated LB4 production from bovine and human PMNL, respectively) by inhibiting FLAP (5-LO-activating protein), rather than 5-LO, activity. Unlike NSAIDs that target only COX pathway, Licofelone does not cause gastrointestinal damages when applied in vivo. |
Catalogue Number | 435801 |
Brand Family | Calbiochem® |
Synonyms | 2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl, 2,3-dihydro-1H-pyrrolizine-5-yl)-acetic acid, ML3000, ML-3000, COX-1 Inhibitor V, FLAP Inhibitor II, mPGES-1 Inhibitor II |
Product Information | |
---|---|
CAS number | 156897-06-2 |
Form | White powder |
Hill Formula | C₂₃H₂₁ClKNO₂•H₂O |
Chemical formula | C₂₃H₂₁ClKNO₂•H₂O |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
---|---|
Primary Target | 5-LOX |
Primary Target IC<sub>50</sub> | 0.21 µ |
Secondary target | COX |
Purity | ≥99% by HPLC |
Physicochemical Information | |
---|---|
Cell permeable | Y |
Packaging Information | |
---|---|
Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
---|---|
Bestellnummer | GTIN |
435801-25MG | 04055977210323 |