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03-229 LSD1 human recombinant

Human recombinant LSD1 expressed in E. Coli.

LSD1 human recombinant: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Key Applications: Enzyme Assays UniProt Number: O60341
03-229
50 µg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesUni Prot Number
      Enzyme AssaysHuman O60341
      Description
      Catalogue Number03-229
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionLSD1 human recombinant
      OverviewHuman recombinant LSD1 expressed in E. Coli
      Background InformationLSD1 catalyzes the oxidative demethylation of mono- and dimethylated H3K4, producing hydrogen peroxide and formaldehyde in the process. H3K4 methylation is considered a transcription-activating chromatin mark, and in vivo LSD1 is frequently found in association with the transcriptional corepressor protein CoREST and HDACs 1 or 2. LSD1 is inhibited by a number of established monoamine oxidase inhibitor drugs. That and the fact that its expression is elevated in a number of cancers may make it a promising target for drug development.
      References
      Product Information
      FormatPurified
      Presentation6 mM Na2HPO4, 1.1 mM K2HPO4, pH 7.2, 82 mM sodium chloride, 1.6 mM KCl and 40% glycerol. Frozen solution.
      Quality LevelMQ100
      Applications
      ApplicationHuman recombinant LSD1 expressed in E. Coli.
      Key Applications
      • Enzyme Assays
      Application NotesDemethylation enzyme assays
      Biological Information
      PurityPurity >90% by SDS-PAGE
      Specific Activity>20U/μg. One U=1 pmol/min at 30ºC as determined by a Peroxidase-Coupled Assay with a Histone H3 dimethyl lysine 4 peptide.
      UniProt Number
      Molecular Weight~78 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 12 months at -80ºC from date of receipt. The enzyme is stable on ice for 30 to 60 min, but may lose activity with prolonged storage on ice. It is recommended that thawing and dilution of the enzyme be done within as short a time as possible before start of the assay. The remaining, unused, undiluted enzyme should be refrozen quickly by, for example, snap freezing in a dry/ice ethanol bath or liquid nitrogen. Freezing and storage of diluted enzyme is not recommended.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      03-229 04053252550904