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422175 L-165,041 - CAS 79558-09-1 - Calbiochem

A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (Ki = 6 nM for hPPARδ and 730 nM for hPPARγ).

L-165,041 - CAS 79558-09-1 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: Compound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII

Primary Target: Peroxisome proliferator activator receptor δ (PPAR@delta;)
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422175
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
79558-09-1C₂₂H₂₆O₇

Preis & Verfügbarkeit

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422175-5MG
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      Description
      OverviewA cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (Ki = 6 nM for hPPARδ and 730 nM for hPPARγ). Potently induces adipocyte differentiation in NIH-PPARδ cells at 500 nM and raises total cholesterol in insulin resistant db/db mice without altering glucose or triglycerides levels. Increases UCP3 (uncoupling protein 3) gene expression in L6 myotubes. Inhibits cytokine-induced expression of VCAM-1 (vascular cell adhesion molecule-1) and the secretion of MCP-1 (monocyte chemotactic protein-1) in EAhy926 cells.
      Catalogue Number422175
      Brand Family Calbiochem®
      SynonymsCompound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII
      References
      ReferencesRival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143.
      Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082.
      Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175.
      Son, C., et al. 2001. Endocrinology 142, 4189.
      Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
      Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333.
      Berger, J., et al. 1999. J. Biol. Chem. 274, 6718.
      Lim, H., et al. 1999. Genes Dev. 13, 1561.
      Product Information
      CAS number79558-09-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₂H₂₆O₇
      Chemical formulaC₂₂H₂₆O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPeroxisome proliferator activator receptor δ (PPAR@delta;)
      Primary Target K<sub>i</sub>6 nM for hPPARδ and 730 nM for hPPARγ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      422175-5MG 04055977187144

      Documentation

      L-165,041 - CAS 79558-09-1 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      L-165,041 - CAS 79558-09-1 - Calbiochem Analysenzertifikate

      TitelChargennummer
      422175

      Literatur

      Übersicht
      Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143.
      Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082.
      Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175.
      Son, C., et al. 2001. Endocrinology 142, 4189.
      Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
      Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333.
      Berger, J., et al. 1999. J. Biol. Chem. 274, 6718.
      Lim, H., et al. 1999. Genes Dev. 13, 1561.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-August-2008 RFH
      SynonymsCompound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII
      DescriptionA cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (Ki = 6 nM for hPPAR δ and 730 nM for hPPARγ). Induces adipocyte differentiation in NIH-PPARδ cells at 500 nM. Also reported to raise total cholesterol in insulin-resistant db/db mice without altering glucose or triglyceride levels. Shown to increase uncoupling protein 3 (UCP3) gene expression in L6 myotubes. Also shown to inhibit cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) and the secretion of monocyte chemotactic protein-1 (MCP-1) in Eahy926 cells.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number79558-09-1
      Chemical formulaC₂₂H₂₆O₇
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml) or 1 N NaOH (40 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesRival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143.
      Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082.
      Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175.
      Son, C., et al. 2001. Endocrinology 142, 4189.
      Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
      Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333.
      Berger, J., et al. 1999. J. Biol. Chem. 274, 6718.
      Lim, H., et al. 1999. Genes Dev. 13, 1561.