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508507 Isradipine - CAS 75695-93-1 - Calbiochem

A voltage gated calcium channel gating inhibitor of the dihydropyridine class.

Isradipine - CAS 75695-93-1 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: L-type voltage-gated Ca2+ channel blocker, Isradipine, PN 200-110

Primary Target: CaV
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508507
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Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
75695-93-1C₁₉H₂₁N₃O₅

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      Description
      OverviewA water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC50 of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number508507
      Brand Family Calbiochem®
      SynonymsL-type voltage-gated Ca2+ channel blocker, Isradipine, PN 200-110
      References
      ReferencesChan, C. S. et al. 2007. Nature. 447, 1081.
      Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci. 45, 708.
      Koschak, A. et al. 2003. J. Neurosci./i> 23, 6041.
      Koschak, A. et al. 2001. J. Biol Chem 276, 22100.
      Product Information
      CAS number75695-93-1
      FormYellow solid
      Hill FormulaC₁₉H₂₁N₃O₅
      Chemical formulaC₁₉H₂₁N₃O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCaV
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5085070001 04055977262001

      Documentation

      Isradipine - CAS 75695-93-1 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Chan, C. S. et al. 2007. Nature. 447, 1081.
      Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci. 45, 708.
      Koschak, A. et al. 2003. J. Neurosci./i> 23, 6041.
      Koschak, A. et al. 2001. J. Biol Chem 276, 22100.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-January-2014 JSW
      SynonymsL-type voltage-gated Ca2+ channel blocker, Isradipine, PN 200-110
      DescriptionA water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC50 of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.
      FormYellow solid
      CAS number75695-93-1
      Chemical formulaC₁₉H₂₁N₃O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM) or Ethanol (50 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesChan, C. S. et al. 2007. Nature. 447, 1081.
      Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci. 45, 708.
      Koschak, A. et al. 2003. J. Neurosci./i> 23, 6041.
      Koschak, A. et al. 2001. J. Biol Chem 276, 22100.