474788 Sigma-AldrichInSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem
Potent, reversible, and cell-permeable proteasome inhibitor. Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex.
More>> Potent, reversible, and cell-permeable proteasome inhibitor. Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: Proteasome Inhibitor XI
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Übersicht
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Key Spec Table
| Empirical Formula |
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| C₂₆H₄₁N₃O₅ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 474788-10MG |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available. |
| Catalogue Number | 474788 |
| Brand Family | Calbiochem® |
| Synonyms | Proteasome Inhibitor XI |
| Application Data |  |
| Product Information | |
|---|---|
| Form | Liquid |
| Formulation | A 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH. |
| Hill Formula | C₂₆H₄₁N₃O₅ |
| Chemical formula | C₂₆H₄₁N₃O₅ |
| Reversible | Y |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target K<sub>i</sub> | Ki = 4 nM for proteasomal inhibition |
| Secondary target | IKK |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | Z-Leu-Leu-Leu-CHO |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
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| R Phrase | R: 11-22 Highly flammable. Harmful if swallowed. |
| S Phrase | S: 16-7 Keep away from sources of ignition - No Smoking. Keep container tightly closed. |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 474788-10MG | 04055977185461 |
Documentation
InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem SDB
| Titel |
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InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 474788 |
Literatur
| Übersicht |
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| Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476. Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865. Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280. Wiertz, E.J., et al. 1996. Cell 84, 769. Jensen, T.J., et al. 1995. Cell 83, 129. Read, M.A., et al. 1995. Immunity 2, 493. Rock, K.L., et al. 1994. Cell 78, 761. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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