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219675 InSolution™ CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem

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Synonyme: N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide

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219675
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219675-5MG
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      Description
      OverviewA cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.
      Catalogue Number219675
      Brand Family Calbiochem®
      SynonymsN-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
      References
      ReferencesSonawane, N.D., et al. 2006. FASEB J. 20, 130.
      Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.
      Product Information
      CAS number328541-79-3
      FormLiquid
      FormulationA 25 mM (5 mg/406 µL) solution of CFTR Inhibitor II, GlyH-101 (Cat. No. 219671) in DMSO.
      Hill FormulaC₁₉H₁₅Br₂N₃O₃
      Chemical formulaC₁₉H₁₅Br₂N₃O₃
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCFTR
      Primary Target K<sub>i</sub>4.3 µ
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 3 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      219675-5MG 04055977200935

      Documentation

      InSolution™ CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      InSolution™ CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem Analysenzertifikate

      TitelChargennummer
      219675

      Literatur

      Übersicht
      Sonawane, N.D., et al. 2006. FASEB J. 20, 130.
      Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-March-2013 JSW
      SynonymsN-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
      DescriptionA cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.
      FormLiquid
      FormulationA 25 mM (5 mg/406 µL) solution of CFTR Inhibitor II, GlyH-101 (Cat. No. 219671) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number328541-79-3
      Chemical formulaC₁₉H₁₅Br₂N₃O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 3 months at -70°C.
      Toxicity Irritant
      ReferencesSonawane, N.D., et al. 2006. FASEB J. 20, 130.
      Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.