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407621 IL-2Rα Antagonist - CAS 1217448-66-2 - Calbiochem

The IL-2Rα Antagonist, also referenced under CAS 1217448-66-2, controls the biological activity of IL-2Rα.

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Synonyme: (R)-N-(2-(1-(Aminoiminomethyl)-3-piperidinyl)-1-oxoethyl)-4-(phenylethynyl)-L-phenylalanine methyl ester, trifluoroacetate, Ro26-4550

Primary Target: Inhibitor of the IL-2/IL-2Rα interaction
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407621
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
1217448-66-2C₂₆H₃₀N₄O₃ • CF₃CO₂H

Preis & Verfügbarkeit

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407621-5MG
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      Description
      OverviewA non-peptidyl acylphenylalanine compound that binds to IL-2 and acts as a competitive inhibitor of the IL-2/IL-2Rα interaction (IC50 = 3 µM).
      Catalogue Number407621
      Brand Family Calbiochem®
      Synonyms(R)-N-(2-(1-(Aminoiminomethyl)-3-piperidinyl)-1-oxoethyl)-4-(phenylethynyl)-L-phenylalanine methyl ester, trifluoroacetate, Ro26-4550
      References
      ReferencesEmerson, S.D., et al. 2003. Protein Science 12, 811.
      Tilley, J.W., et al. 1997. J. Am. Chem. Soc. 119, 7589.
      Product Information
      CAS number1217448-66-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₆H₃₀N₄O₃ • CF₃CO₂H
      Chemical formulaC₂₆H₃₀N₄O₃ • CF₃CO₂H
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInhibitor of the IL-2/IL-2Rα interaction
      Primary Target IC<sub>50</sub>3 µM against IL-2/IL-2Rα interaction
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      407621-5MG 04055977211368

      Documentation

      IL-2Rα Antagonist - CAS 1217448-66-2 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      IL-2Rα Antagonist - CAS 1217448-66-2 - Calbiochem Analysenzertifikate

      TitelChargennummer
      407621

      Literatur

      Übersicht
      Emerson, S.D., et al. 2003. Protein Science 12, 811.
      Tilley, J.W., et al. 1997. J. Am. Chem. Soc. 119, 7589.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2011 RFH
      Synonyms(R)-N-(2-(1-(Aminoiminomethyl)-3-piperidinyl)-1-oxoethyl)-4-(phenylethynyl)-L-phenylalanine methyl ester, trifluoroacetate, Ro26-4550
      DescriptionA non-peptidyl acylphenylalanine compound that binds to IL-2 and acts as a competitive inhibitor of the IL-2/IL-2Rα interaction (IC50 = 3 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1217448-66-2
      Chemical formulaC₂₆H₃₀N₄O₃ • CF₃CO₂H
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (28 mg/ml) or Ethanol (2 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesEmerson, S.D., et al. 2003. Protein Science 12, 811.
      Tilley, J.W., et al. 1997. J. Am. Chem. Soc. 119, 7589.