382173 Sigma-AldrichHistone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem
The Histone Deacetylase Inhibitor VII, 106, also referenced under CAS 937039-45-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The Histone Deacetylase Inhibitor VII, 106, also referenced under CAS 937039-45-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: N¹-(2-Aminophenyl)-N⁷-p-tolylheptanediamide, Pimelic Diphenylamide 106
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 937039-45-7 | C₂₀H₂₅N₃O₂ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 382173-5MG |
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Kst.-Ampulle | 5 mg |
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| Description | |
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| Overview | A cell-permeable p-tolylbenzamide and a Histone Deacetylase (HDAC) Inhibitor IV (Cat. No. 382170) analog that acts as a selective inhibitor against class I HDAC1,2,3 (IC50 = 0.15, 0.76, and 0.37 µM with 15, 30, and 180 min preincubation, respectively), while exhibiting much lower acitivity against class I HDAC8 (IC50 ≥ 5µM with 3 h preincubation) and no activity against class II HDAC4/5/7 even at concentrations as high as 180µM. Although the mode of inhibition is mechanistically competitive and reversible, due to the slow- and tight-binding nature, long preincubation is often required for effective in vitro enzyme inhibition, while 106-induced cellular H3 hyperacetylation is shown to persist for more than 6 hours after inhibitor removal by washing in GM15850 culture. 106 is reported to be less cytotoxic than TSA (Cat. No. 647925), MS-275, and SAHA (EC50 = 6.3, 0.328, 0.768, and 1.5 µM, respectively, in GM15850 killing). |
| Catalogue Number | 382173 |
| Brand Family | Calbiochem® |
| Synonyms | N¹-(2-Aminophenyl)-N⁷-p-tolylheptanediamide, Pimelic Diphenylamide 106 |
| References | |
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| References | Chou, C.J., et al. 2008. J. Biol. Chem. 283, 35402. |
| Product Information | |
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| CAS number | 937039-45-7 |
| Form | White solid |
| Hill Formula | C₂₀H₂₅N₃O₂ |
| Chemical formula | C₂₀H₂₅N₃O₂ |
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| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Safety Information | |
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| S Phrase | S: 22-24/25-36 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing. |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 382173-5MG | 04055977212792 |
Documentation
Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem SDB
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Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 382173 |
Literatur
| Übersicht |
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| Chou, C.J., et al. 2008. J. Biol. Chem. 283, 35402. |
Technische Informationen
| Titel |
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| White Paper - The Message in the Marks: Deciphering Cancer Epigenetics |