385920 Sigma-AldrichHSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem
The HSP90 Inhibitor, CCT018159, also referenced under CAS 171009-07-7, controls the biological activity of HSP90.
More>> The HSP90 Inhibitor, CCT018159, also referenced under CAS 171009-07-7, controls the biological activity of HSP90. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 171009-07-7 | C₂₀H₂₀N₂O₄ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 385920-5MG |
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Kst.-Ampulle | 5 mg |
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| Description | |
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| Overview | A cell-permeable pyrazoloresorcinol compound that inhibits HSP90 ATPase activity (IC50 = 3.2 µM and 6.6 µM against human HSP90β and yeast HSP90, respectively) by targeting the enzyme's N-terminal ATP binding site. It exhibits no detectable effects against human Hsp70 or topoisomerase II even at concentrations as high as 100 µM and inhibits a panel of 20 commonly studied kinases only at much higher concentrations. Unlike 17-AAG (Cat. No. 100068), the antitumor activity of CCT018159 is not affected by the expression of NQ01/DT-diaphorase or P-glycoprotein. |
| Catalogue Number | 385920 |
| Brand Family | Calbiochem® |
| Synonyms | 4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol |
| Product Information | |
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| CAS number | 171009-07-7 |
| Form | White solid |
| Hill Formula | C₂₀H₂₀N₂O₄ |
| Chemical formula | C₂₀H₂₀N₂O₄ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥98% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 385920-5MG | 04055977189841 |
Documentation
HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem SDB
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HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 385920 |
Literatur
| Übersicht |
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| Hardcastle, A., et al. 2007. Mol. Cancer Ther. 6, 1112. Sharp, S.Y., et al. 2007. Cancer Res. 67, 2206. Smith, N.F., et al. 2006. Mol. Cancer Ther. 5, 1628. Dymock, B.W., et al. 2005. J. Med. Chem. 48, 4212. Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3338. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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