505760 Sigma-AldrichHDAC6 Inhibitor II, BRD9757 - CAS 1423058-85-9 - Calbiochem
Empfohlene Produkte
Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 1423058-85-8 | C₆H₉NO₂ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 5057600001 |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | A cell-permeable, low molecular weight hydroxamate compound that acts as a potent histone deacetylase class IIb HDAC6-selective inhibitor (IC50 = 30 nM), while inhibiting class I HDAC1/2/3/8 only at higher concentrations (IC50 = 0.638, 1.79, 0.694, and 1.09 µM, respectively) and exhibiting much reduced potency against class IIa HDAC4/5/7/9 (IC50 >12.61 µM). Shown to selectively upregulate HDAC6 substrate α-tubulin acetylation in HeLa cells (10 & 30 µM; 24 h) without inducing histone H3 acetylation increase seen with another HDAC6-selective inhibitor Tubastatin A (Cat. No. 382187). Unlike other Zinc-binding group-containing HDAC inhibitors, BRD9757 does not contain an apparent selectivity-imparting capping structure linked to its hydroxamate. |
| Catalogue Number | 505760 |
| Brand Family | Calbiochem® |
| Synonyms | HDAC Inhibitor XVI, Histone Deacetylase Inhibitor XVI, N-Hydroxycyclopent-1-enecarboxamide |
| References | |
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| References | Wagner, F.F., et al. 2013. J. Med. Chem. 56, 1772. |
| Product Information | |
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| CAS number | 1423058-85-8 |
| Form | Pale orange solid |
| Hill Formula | C₆H₉NO₂ |
| Chemical formula | C₆H₉NO₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | HDAC6 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 5057600001 | 04055977243505 |
Documentation
HDAC6 Inhibitor II, BRD9757 - CAS 1423058-85-9 - Calbiochem SDB
| Titel |
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Literatur
| Übersicht |
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| Wagner, F.F., et al. 2013. J. Med. Chem. 56, 1772. |
Technische Informationen
| Titel |
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| White Paper - The Message in the Marks: Deciphering Cancer Epigenetics |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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