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344281 Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem

A cell-permeable and water-soluble Forskolin derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC.

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Synonyme: 6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl

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344281
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
138605-00-2C₂₇H₄₃NO₈ • HCl

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      Description
      OverviewA cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.
      Catalogue Number344281
      Brand Family Calbiochem®
      Synonyms6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl
      References
      ReferencesNakashima, S., et al. 2005. J. Heart Lung Transplant. 24, 462.
      Morinobu, S., et al. 1999. J. Neurochem. 72, 2198.
      Satake, K., et al. 1998. Br. J. Pharmacol. 123, 753.
      Toya, Y., et al. 1998. J. Mol. Cell Cardiol. 30, 97.
      Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev. 13, 339.
      Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19, 625.
      Shafiq, J., et al. 1992. Circ. Res. 71, 70.
      Hosono, M., et al. 1990. Eur. J. Pharmacol. 183, 2110.
      Product Information
      CAS number138605-00-2
      FormWhite solid
      Hill FormulaC₂₇H₄₃NO₈ • HCl
      Chemical formulaC₂₇H₄₃NO₈ • HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 26/27/28-62-63

      Very toxic by inhalation, in contact with skin and if swallowed.
      Possible risk of impaired fertility.
      Possible risk of harm to the unborn child.
      S PhraseS: 22-24/25-36/37/39-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      344281-5MG 04055977214673

      Documentation

      Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem Analysenzertifikate

      TitelChargennummer
      344281

      Literatur

      Übersicht
      Nakashima, S., et al. 2005. J. Heart Lung Transplant. 24, 462.
      Morinobu, S., et al. 1999. J. Neurochem. 72, 2198.
      Satake, K., et al. 1998. Br. J. Pharmacol. 123, 753.
      Toya, Y., et al. 1998. J. Mol. Cell Cardiol. 30, 97.
      Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev. 13, 339.
      Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19, 625.
      Shafiq, J., et al. 1992. Circ. Res. 71, 70.
      Hosono, M., et al. 1990. Eur. J. Pharmacol. 183, 2110.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2010 RFH
      Synonyms6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl
      DescriptionA cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number138605-00-2
      Chemical formulaC₂₇H₄₃NO₈ • HCl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityH₂O (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Highly Toxic
      ReferencesNakashima, S., et al. 2005. J. Heart Lung Transplant. 24, 462.
      Morinobu, S., et al. 1999. J. Neurochem. 72, 2198.
      Satake, K., et al. 1998. Br. J. Pharmacol. 123, 753.
      Toya, Y., et al. 1998. J. Mol. Cell Cardiol. 30, 97.
      Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev. 13, 339.
      Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19, 625.
      Shafiq, J., et al. 1992. Circ. Res. 71, 70.
      Hosono, M., et al. 1990. Eur. J. Pharmacol. 183, 2110.