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341310 FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem

The FABP4 Inhibitor, also referenced under CAS 300657-03-8, controls the biological activity of FABP4.

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Synonyme: adipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      300657-03-8C₃₁H₂₆N₂O₃
      Description
      OverviewA cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.
      Catalogue Number341310
      Brand Family Calbiochem®
      Synonymsadipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
      References
      ReferencesFuruhashi, M., et al. 2007. Nature 447, 959.
      Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.
      Product Information
      CAS number300657-03-8
      FormWhite solid
      Hill FormulaC₃₁H₂₆N₂O₃
      Chemical formulaC₃₁H₂₆N₂O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      341310 0

      Documentation

      FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem Analysenzertifikate

      TitelChargennummer
      341310

      Literatur

      Übersicht
      Furuhashi, M., et al. 2007. Nature 447, 959.
      Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-October-2008 JSW
      Synonymsadipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
      DescriptionA cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number300657-03-8
      Chemical formulaC₃₁H₂₆N₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml), Methanol (50 mg/ml), or Ethanol (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesFuruhashi, M., et al. 2007. Nature 447, 959.
      Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.