324414 Sigma-AldrichDynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem
The Dynamin Inhibitor V, 34-2 controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.
More>> The Dynamin Inhibitor V, 34-2 controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide
Empfohlene Produkte
Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 1128165-88-7 | C₂₅H₃₆N₄O |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 324414-10MG |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | A cell-permeable, allosteric Dynamin inhibitor (IC50 = 6.9 µM and 14 µM for full length Dynamin I and Dynamin II GTPase activity, respectively, in vitro). 10 µM of this compound results in cytokinesis failure at the abscission stage in HeLa cultures, with 82% of cells that enter into mitosis becoming multinucleated, and with 97% resulting in cell death. However, it displays a much reduced effect in NIH3T3 cells at the same concentration. It elicits a dose-dependent reduction in cell growth against SMA-560, SJ-G2, SW480, MCF-7 and A2780 cultures, as being the most sensitive among a panel of other cancer cell lines (GI50 = 4.0–37 µM). It was further shown to be 6-fold more active (IC50 = 5.0 µM) than dynamin mediated receptor mediated endocytosis (RME) in U2OS cells, and 15-fold more active (IC50 = 1.3 µM) than Dynasore (Cat. No. 324410) in another Dynamin I GTPase activity assay. |
| Catalogue Number | 324414 |
| Brand Family | Calbiochem® |
| Synonyms | 2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide |
| References | |
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| References | Chircop, M. et al. 2011. Mol. Cancer Ther. 10, 1553. Hill, T.A., et al. 2009. J. Med. Chem. 52, 3762. |
| Product Information | |
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| CAS number | 1128165-88-7 |
| Form | Yellow solid |
| Hill Formula | C₂₅H₃₆N₄O |
| Chemical formula | C₂₅H₃₆N₄O |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥99% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 324414-10MG | 04055977197204 |
Documentation
Dynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem SDB
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Dynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 324414 |
Literatur
| Übersicht |
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| Chircop, M. et al. 2011. Mol. Cancer Ther. 10, 1553. Hill, T.A., et al. 2009. J. Med. Chem. 52, 3762. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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