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371206 Dkk-1, His•Tag®, Mouse, Recombinant

Dkk-1, His•Tag®, Mouse, Recombinant, consists of amino acids 30-272, fused at the C-terminus to a His•Tag® sequence, and expressed in NS0-dervied mouse myeloma cells.

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371206
Preis & Verfügbarkeit

Übersicht

Key Spec Table

Purity
≥95% by SDS-PAGE

Preis & Verfügbarkeit

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371206-10UG
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      Description
      OverviewRecombinant, murine Dickkopf related protein-1 (Dkk-1), consisting of amino acids 30-272, fused at the C-terminus to a His•Tag® sequence, and expressed in NS0-dervied mouse myeloma cells. Dkk-1 is a well-documented antagonist of the Wnt signaling pathway. The balance between Dkk-1 inhibition and Wnt signaling is essential for bone formation and homeostasis.
      Catalogue Number371206
      Brand Family Calbiochem®
      References
      ReferencesPinzone, J.J. et al. 2009. Blood 113, 517.
      Li, J. et al. 2006. Bone 36, 754.
      Morvan, F. et al. 2006. J. Bone Miner. Res. 21, 934.
      Niehrs, C. 2006. Oncogene 25, 7469.
      Verani, R. et al. 2006. J. Neurochem. 101, 242.
      Cappuccio, I. et al. 2005. J. Neurosci. 25, 2647.
      Kemp, C. et al. 2005. Dev. Dyn. 233, 1064.
      Adamska, M. et al. 2004. Dev. Biol. 272, 134.
      Bullock, C.M. et al. 2004. Mol. Pharmacol. 65, 582.
      Mao, B. et al. 2002. Nature 417, 664.
      Mao, B. et al. 2001. Nature 411, 321.
      Glinka, A. et al. 1998. Nature 391, 357.
      Product Information
      FormLyophilized
      FormulationLyophilized from 0.2 µm filtered PBS, BSA.
      Quality LevelMQ100
      Biological Information
      Biological activityND₅₀: 0.2-1 µg/ml as measured by the inhibition of Wnt-3a-induced alkaline phosphatase production in MC3T3-E1 mouse osteoblastic cells.
      Reduction of Axis-inducing activity: 60-100% reduction (using 1 ng rmDkk-1 per embryo) in the number of secondary axes produced in the presence of 10-20 pg Xwnt-8 mRNA using early Xenopus embryos.
      Purity≥95% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤1.0 EU/µg protein
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Global Trade Item Number
      Bestellnummer GTIN
      371206-10UG 04055977191783