662143 Sigma-AldrichDUB Inhibitor XI
A cell-permeable compound that acts as a dual inhibitor of USP7 (IC₅₀ = 0.42 µM) and USP47 (IC₅₀ = 1.0 µM).
More>> A cell-permeable compound that acts as a dual inhibitor of USP7 (IC₅₀ = 0.42 µM) and USP47 (IC₅₀ = 1.0 µM). Less<<DUB Inhibitor XI: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: USP7 Inhibitor III, 4-Cyano-5-((3,5-dichloropyridin-4-yl)thio)-N-(4-(methylsulfonyl)phenyl)thiophene-2-carboxamide, USP47 Inhibitor III
Empfohlene Produkte
Übersicht
| Replacement Information |
|---|
Key Spec Table
| Empirical Formula |
|---|
| C₁₈H₁₁Cl₂N₃O₃S₃ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 662143-10MG |
|
Glasflasche | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable dichloropyridinylthio-thiophenecarboxamide that is more potent than DUB Inhibitor VI, P22077 (Cat. No. 662142) as a dual inhibitor against USP7 (IC50 = 0.42 vs. 8.0 µM with respective inhibitor) and USP47 (IC50 = 1.0 vs. 8.7 µM with respective inhibitor), while exhibiting comparable cytotoxicity toward HCT-116 (CC50 = 7.6 vs. 7.8 µM with respective inhibitor) by upregulating cellular p21 and p53 protein levels in a time-dependent manner. Displays little potency against USP2, USP5, USP8, USP21 USP28, cathepsin B, caspase-3, calpain-1, or 20S proteasome chymotrypsin-like activity (IC50 >31.6 µM). |
| Catalogue Number | 662143 |
| Brand Family | Calbiochem® |
| Synonyms | USP7 Inhibitor III, 4-Cyano-5-((3,5-dichloropyridin-4-yl)thio)-N-(4-(methylsulfonyl)phenyl)thiophene-2-carboxamide, USP47 Inhibitor III |
| References | |
|---|---|
| References | Weinstock, J., et al. 2012. ACS Med. Chem. Lett. 3, 789. |
| Product Information | |
|---|---|
| Form | Pale yellow solid |
| Hill Formula | C₁₈H₁₁Cl₂N₃O₃S₃ |
| Chemical formula | C₁₈H₁₁Cl₂N₃O₃S₃ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | USP7/47 |
| Primary Target IC<sub>50</sub> | 0.42 and 1.0 µ |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Bestellnummer | GTIN |
| 662143-10MG | 04055977261264 |
Documentation
DUB Inhibitor XI SDB
| Titel |
|---|
DUB Inhibitor XI Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 662143 |
Literatur
| Übersicht |
|---|
| Weinstock, J., et al. 2012. ACS Med. Chem. Lett. 3, 789. |
| Datenblatt | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|