Millipore Sigma Vibrant Logo

310500 D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem

A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: DMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III

View Products on Sigmaaldrich.com
310500
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
119567-63-4C₂₀H₄₁NO₂

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
310500-5MG
Verfügbarkeit wird abgerufen...
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      		 Kst.-Ampulle 5 mg
      Preis wird abgerufen...
      Preis nicht abrufbar
      Die Mindestmenge muss ein Vielfaches sein von
      Maximum Quantity is
      Bei Bestätigung Weitere Informationen
      Sie haben () gespart
       
      —
      Bitte erfragen
      		 —
      Description
      OverviewA cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.
      Catalogue Number310500
      Brand Family Calbiochem®
      SynonymsDMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
      References
      ReferencesCuvillier, O., et al. 1996. Nature 381, 800.
      Ohta, H., et al. 1995. Cancer Res. 55, 691.
      Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
      Hanada, K., et al. 1991. Biochemistry 30, 11682.
      Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.
      Product Information
      CAS number119567-63-4
      ATP CompetitiveN
      FormWaxy solid/Clear oil
      Hill FormulaC₂₀H₄₁NO₂
      Chemical formulaC₂₀H₄₁NO₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>12 µM against PKC
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      310500-5MG 04055977216837

      Documentation

      D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem Analysenzertifikate

      TitelChargennummer
      310500

      Literatur

      Übersicht
      Cuvillier, O., et al. 1996. Nature 381, 800.
      Ohta, H., et al. 1995. Cancer Res. 55, 691.
      Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
      Hanada, K., et al. 1991. Biochemistry 30, 11682.
      Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.

      Broschüre

      Titel
      Bioactive Lipids Technical Bulletin
      Caspases and other Apoptosis Related Tools Brochure
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2010 RFH
      SynonymsDMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
      DescriptionA cell-permeable and reversible inhibitor of protein kinase C (IC50 = 12 µM) and enhances src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells.
      FormWaxy solid/Clear oil
      CAS number119567-63-4
      Chemical formulaC₂₀H₄₁NO₂
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (5 mg/ml), Ethanol, or Methanol
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Toxicity Irritant
      ReferencesCuvillier, O., et al. 1996. Nature 381, 800.
      Ohta, H., et al. 1995. Cancer Res. 55, 691.
      Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
      Hanada, K., et al. 1991. Biochemistry 30, 11682.
      Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.