218759 Sigma-AldrichCaspase-8 Inhibitor II - Calbiochem
Caspase-8 Inhibitor II, CAS 210344-98-2, is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B.
More>> Caspase-8 Inhibitor II, CAS 210344-98-2, is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B. Less<<Caspase-8 Inhibitor II - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: Z-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
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Übersicht
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Key Spec Table
| Empirical Formula |
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| C₃₀H₄₃FN₄O₁₁ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 218759-1MG |
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Kst.-Ampulle | 1 mg |
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| 218759-250UG |
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Glasflasche | 250 μg |
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| Description | |
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| Overview | A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available. |
| Catalogue Number | 218759 |
| Brand Family | Calbiochem® |
| Synonyms | Z-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III |
| Product Information | |
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| ATP Competitive | N |
| Form | White to yellow powder |
| Hill Formula | C₃₀H₄₃FN₄O₁₁ |
| Chemical formula | C₃₀H₄₃FN₄O₁₁ |
| Reversible | N |
| Quality Level | MQ100 |
| Applications | |
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| Application | Caspase-8 Inhibitor II, CAS 210344-98-2, is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B. |
| Biological Information | |
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| Primary Target | caspase-8 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F* |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 218759-1MG | 04055977218619 |
| 218759-250UG | 04055977218626 |
Documentation
Caspase-8 Inhibitor II - Calbiochem SDB
| Titel |
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Caspase-8 Inhibitor II - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 218759 |
Literatur
| Übersicht |
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| Takizawa, T., et al. 1999. Microbiol. Immunol. 43, 245. Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345. Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. |
Broschüre
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| Caspases and other Apoptosis Related Tools Brochure |
Literaturstellen
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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