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400011 Caspase-1 Inhibitor I, Cell-Permeable - Calbiochem

Caspase-1 Inhibitor I, Cell-Permeable, inhibits the activity of caspase-1 (Ki = 1 nM), 4 & 5. The N-terminal corresponds to the h-region of the signal peptide of K-FGF that confers cell-permeabili

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Synonyme: ICE Inhibitor I, Cell-permeable, YVAD-CHO, Cell-permeable, Ac-AAVALLPAVLLALLAPYVAD-CHO

Primary Target: Caspase-1
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400011
Preis & Verfügbarkeit

Übersicht

Key Spec Table

Empirical Formula
C₉₇H₁₆₀N₂₀O₂₄

Preis & Verfügbarkeit

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400011-1MG
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      Description
      OverviewA cell-permeable inhibitor of caspase-1 (ICE; Interleukin-1β Converting Enzyme), caspase-4, and caspase-5. The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (Ki = 1 nM). The N-terminal sequence (amino acid residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of the Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
      Catalogue Number400011
      Brand Family Calbiochem®
      SynonymsICE Inhibitor I, Cell-permeable, YVAD-CHO, Cell-permeable, Ac-AAVALLPAVLLALLAPYVAD-CHO
      References
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
      Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
      Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43, 87.
      Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
      Thornberry, N.A., et al. 1994. Methods Enzymol. 244, 615.
      Thornberry, N.A., et al. 1992. Nature 356, 768.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₉₇H₁₆₀N₂₀O₂₄
      Chemical formulaC₉₇H₁₆₀N₂₀O₂₄
      ReversibleY
      Quality LevelMQ100
      Applications
      ApplicationCaspase-1 Inhibitor I, Cell-Permeable, inhibits the activity of caspase-1 (Ki = 1 nM), 4 & 5. The N-terminal corresponds to the h-region of the signal peptide of K-FGF that confers cell-permeability.
      Biological Information
      Primary TargetCaspase-1
      Primary Target K<sub>i</sub>1 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Global Trade Item Number
      Bestellnummer GTIN
      400011-1MG 04055977212624