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538763 CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem

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Synonyme: Compound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor

Primary Target: CD38
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538763
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Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
1700637-55-3C₂₂H₂₇N₃O₃S

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      Description
      OverviewA cell-permeable, orally bioavailable, non-toxic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC50 = 7.3 & 1.9 nM for human & mouse CD38, respectively; Ki = 0.3 nM for human wt-CD38). Shown to bind to the catalytic active site. Displays attractive PK properties in mice (p.o. 30 mg/kg: t1/2 = 3.5 h, Cmax = 10.8 µg/ml; i.v. 2 mg/kg: t1/2 = 5.3 h, Cmax = 2.98 µg/ml, Cl = 21 ml/min/kg, Vdss = 1.3 L/kg). Rapidly elevates NAD levels by several folds in both liver and gastrocnemius tissue in a diet induced obese mouse (30 mg/kg, p.o.).
      Catalogue Number538763
      Brand Family Calbiochem®
      SynonymsCompound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor
      References
      ReferencesHaffner, C.D., et al. 2015. J. Med. Chem. 58, 3548.
      Tarrago, M.G., et al. 2018 Cell. Metab. 27, 1081.
      Product Information
      CAS number1700637-55-3
      FormWhite to light brown to brown solid
      Hill FormulaC₂₂H₂₇N₃O₃S
      Chemical formulaC₂₂H₂₇N₃O₃S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCD38
      Primary Target IC<sub>50</sub>7.3 & 1.9 nM for human & mouse CD38, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5387630001 04054839119507

      Documentation

      CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem Analysenzertifikate

      TitelChargennummer
      538763

      Literatur

      Übersicht
      Haffner, C.D., et al. 2015. J. Med. Chem. 58, 3548.
      Tarrago, M.G., et al. 2018 Cell. Metab. 27, 1081.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-July-2019 JSW
      SynonymsCompound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor
      DescriptionA cell-permeable, orally bioavailable, non-toxic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC50 = 7.3 & 1.9 nM for human & mouse CD38, respectively; Ki = 0.3 nM for human wt-CD38). Shown to bind to the catalytic active site. Displays attractive PK properties in mice (p.o. 30 mg/kg: t1/2 = 3.5 h, Cmax = 10.8 µg/ml; i.v. 2 mg/kg: t1/2 = 5.3 h, Cmax = 2.98 µg/ml, Cl = 21 ml/min/kg, Vdss = 1.3 L/kg). Rapidly elevates NAD levels by several folds in both liver and gastrocnemius tissue in a diet induced obese mouse (30 mg/kg, p.o.).
      FormWhite to light brown to brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1700637-55-3
      Chemical formulaC₂₂H₂₇N₃O₃S
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHaffner, C.D., et al. 2015. J. Med. Chem. 58, 3548.
      Tarrago, M.G., et al. 2018 Cell. Metab. 27, 1081.