Millipore Sigma Vibrant Logo

ABS82-AF647 Anti-VEGF Antibody, Alexa Fluor® 647 Conjugate

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: VEGFA, VEGF UniProt Number: P15692
View Products on Sigmaaldrich.com
ABS82-AF647
100 µL  
Preis wird abgerufen...
Preis nicht abrufbar
Die Mindestmenge muss ein Vielfaches sein von
Maximum Quantity is
Bei Bestätigung Weitere Informationen
Sie haben () gespart
 
—
Bitte erfragen
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      Sonderaktionen

       

      Kontakt zum Kundenservice

      Übersicht

      Replacement Information

      Sonderaktionen

      100% Performance Guaranteed

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RICCRbAlexaFluor®647Polyclonal Antibody
      Description
      Catalogue NumberABS82-AF647
      DescriptionAnti-VEGF Antibody, Alexa Fluor® 647 Conjugate
      Alternate Names
      • Vascular endothelial growth factor A
      • VEGF-A
      • Vascular permeability factor
      • VPF
      • VEGF, Alexa Fluor® 647 Conjugate
      Background InformationVEGF (Vascular endothelial growth factor, VEGFA, VEGF-A), a dimeric ligand, is among the most potent angiogenic mitogens. VEGF is secreted by tumor cells and other cells exposed to hypoxia. VEGF is a highly specific mitogen for vascular endothelial cells. Seven VEGF isoforms (a, b, c, d, e, f, g) are generated as a result of alternative splicing from a single VEGF gene. The most commonly studied isoforms are VEGF121, VEGF165, and VEGF189 (f, d and b, respectively). All seven isoforms differ in their molecular mass and in biological properties such as their ability to bind to cell-surface heparan-sulfate proteoglycans. The expression of VEGF is potentiated and is secreted by tumor cells in response to hypoxia, by activated oncogenes, and by a variety of cytokines. VEGF induces angiogenesis as well as permeabilization of blood vessels, and also plays a central role in the regulation of vasculogenesis. VEGF expression correlates to the degree of tumor vascularization and with increased metastatic risk. Additionally, VEGF induces endothelial cell proliferation, promotes cell migration, and inhibits apoptosis. Consequently, inhibition of VEGF signaling abrogates the development of a wide variety of tumors.
      References
      Product Information
      FormatAlexaFluor®647
      PresentationPurified rabbit antibody conjugate in PBS with 15mg/ml BSA and 0.1 % sodium azide.
      Quality LevelMQ100
      Applications
      Key Applications
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:100 dilution from a representative lot detected VEGF in A431 and NIH/3T3 cells.
      The unconjugated antibody (Cat. No. ABS82) is shown to be suitable also for Western blotting and immunohistochemistry (Paraffin) applications.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human VEGF at the N-terminus.
      EpitopeN-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis antibody recognizes VEGF at the N-terminus.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteHuman, Mouse, Rat. Predicted to react with Non-Human Primate based on 100% sequence homology. Other homologies: Other homologies: Bovine (85% sequence homology). Rat (70% sequence homology). Mouse (65% sequence homology). Predicted to react with primate based on 100% sequence homology..
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • VEGFA
      • VEGF
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~55 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in HeLa cells.

      Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected VEGF in HeLa cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABS82-AF647 04055977311945

      Documentation

      Anti-VEGF Antibody, Alexa Fluor® 647 Conjugate SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-VEGF Antibody, Alexa Fluor® 647 Conjugate Analysenzertifikate

      TitelChargennummer
      Anti-VEGF, Alexa Fluor® 647 -Q2636951 Q2636951
      Anti-VEGF, Alexa Fluor® 647 Conjugate - 3269420 3269420
      Anti-VEGF, Alexa Fluor® 647 Conjugate - 3474109 3474109
      Anti-VEGF, Alexa Fluor® 647 Conjugate - 3697934 3697934
      Anti-VEGF, Alexa Fluor® 647 Conjugate - 3749943 3749943
      Anti-VEGF, Alexa Fluor® 647 Conjugate - 4078187 4078187
      Anti-VEGF, Alexa Fluor® 647 Conjugate - 4139146 4139146

      Verwandte Produkte & Anwendungen

      Related Products

      Bestellnummer Beschreibung  
      05-1116 Anti-VEGF Antibody, clone CH-10 Preis & Verfügbarkeit
      05-1117 Anti-VEGF Antibody, clone VG1 Preis & Verfügbarkeit
      05-443 Anti-VEGF Antibody, clone JH Preis & Verfügbarkeit
      07-1420 Anti-VEGF Antibody Preis & Verfügbarkeit
      ABS82 Anti-VEGF Antibody Preis & Verfügbarkeit
      ABS82-AF488 Anti-VEGF Antibody, Alexa Fluor® 488 Conjugate Preis & Verfügbarkeit
      MABC595 Anti-VEGF 165b Antibody, clone 56/1 Preis & Verfügbarkeit

      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies