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AB2283 Anti-Tbr2 Antibody

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AB2283
100 µg  
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      Übersicht

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HIHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2283
      DescriptionAnti-Tbr2 Antibody
      Alternate Names
      • eomesodermin (Xenopus laevis) homolog
      • eomesodermin homolog (Xenopus laevis)
      • t box, brain, 2
      Background InformationTbr2 (a T-domain transcription factor) is a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Trb2 has been shown to play a role in the development of the neocortex and functions in the differentiation pathway of radial glia to postmitotic projection neuron.
      Product Information
      FormatAffinity Purified
      Control
      • Human Brain Tissue
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Tbr2 Antibody is validated for use in IH for the detection of Tbr2.
      Key Applications
      • Immunohistochemistry
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to mouse Tbr2.
      EpitopeInternal Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Tbr2.
      Species Reactivity
      • Mouse
      • Human
      Species Reactivity NoteProven to react with human and mouse.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • eomes
      • TBR2
      • eomesodermin
      • tbr1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.

      SUBCELLULAR LOCATION: Nucleus Probable.

      TISSUE SPECIFICTY: Expressed in CD8+ T-cells.

      DEVELOPMENTAL STAGE: Originally expressed in the trophoectoderm of the blastocyst and later in the extra-embryonic ectoderm of the early post-implantation embryo. In the embryo proper, expressed in the posterior part of the epiblast. During gastrulation, extends distally into the primitive streak and nascent mesoderm. Also expressed in the developing forebrain and the olfactory lobes. Expressed at E12.5 and E14.5 in the forebrain.

      INDUCTION: Up-regulated in CD8+ T-cells upon activation.

      DISRUPTION PHENOTYPE: Embryonic lethal due to peri-implantation defects. Mutant embryos arrest soon after implantation and fail to form organized embryonic or extraembryonic structures. Conditional mutants, with expression abrogated in the inner cell mass of embryos from early implantation stages onward, display gastrulation defects.

      SEQUENCE SIMLARITIES: Contains 1 T-box DNA-binding domain.
      Molecular WeightN/A
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry of human brain tissue.

      Immunohistochemistry Analysis: A 1:300 dilution of Anti-Tbr2 antibody from a previous lot detected Tbr2 in mouse and human brain tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Bestellnummer GTIN
      AB2283 04053252729454