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MABF1458 Anti-TCR beta chain (mouse), violetFluor™ 450, clone H57-597 Antibody

This armenian hamster monoclonal Anti-TCR beta chain Antibody (mouse), violetFluor™ 450, clone H57-597, Cat. No. MABF1458 is validated for use in Flow Cytometry, for the detection of TCR beta chain.

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Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: Ptcra UniProt Number: P0C6B2
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MABF1458
25 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFCAHmvioletFluor™ 450Monoclonal Antibody
      Description
      Catalogue NumberMABF1458
      DescriptionAnti-TCR beta chain (mouse), violetFluor™ 450, clone H57-597 Antibody
      Alternate Names
      • Pre T-cell antigen receptor alpha (pT-alpha or pTa)
      • gp33
      • pT-alpha-TCR
      • TCR beta chain
      Background InformationThe H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.
      References
      Product Information
      FormatvioletFluor™ 450
      PresentationPurified Armenian Hamster monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
      Quality LevelMQ100
      Applications
      ApplicationThis armenian hamster monoclonal Anti-TCR beta chain Antibody (mouse), violetFluor™ 450, clone H57-597, Cat. No. MABF1458 is validated for use in Flow Cytometry, for the detection of TCR beta chain.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenImmunogen information for this antibody is proprietary information.
      CloneH57-597
      ConcentrationPlease refer to lot specific datasheet.
      HostArmenian Hamster
      IsotypeIgG
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • Ptcra
      Purification MethodPurified by size-exclusion chromatography
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThis monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

      Flow Cytometry Analysis: 0.25 μg from a representative lot detected TCR beta chain in one million C57Bl/6 splenocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABF1458 04055977291780