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07-1813 Anti-Septin-2 Antibody

Use Anti-Septin-2 Antibody (Rabbit Polyclonal Antibody) validated in WB, IF to detect Septin-2 also known as Neural precursor cell expressed developmentally down-regulated protein 5, septin 2.

Anti-Septin-2 Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Cell Cycle, DNA Replication & Repair, Cell Cycle, DNA Replication & Repair Gene Symbol: SEPT2, DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5 UniProt Number: Q15019
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07-1813
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IFRbSerumPolyclonal Antibody
      Description
      Catalogue Number07-1813
      DescriptionAnti-Septin-2 Antibody
      Alternate Names
      • Neural precursor cell expressed developmentally down-regulated protein 5
      • neural precursor cell expressed, developmentally down-regulated 5
      • septin 2
      Background InformationSeptin-2 belongs to the septin family of GTPases. Originally characterized as regulators of cytokinesis, septins were later implicated in other cellular processes. Recent studies show that septins have a broader role in microtubule-dependent processes, such as karyokinesis, exocytosis, and maintenance of cell shape. Many members of the septin family have been shown to colocalize or interact with the microtubule cytoskeleton, suggesting that these might be general properties of septins. Septin-2 is expressed in the brain and may be associated with Alzheimer's disease.
      References
      Product Information
      FormatSerum
      Control
      • Hek293 cell lysate
      PresentationUnpurified rabbit polyclonal with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-Septin-2 Antibody (Rabbit Polyclonal Antibody) validated in WB, IF to detect Septin-2 also known as Neural precursor cell expressed developmentally down-regulated protein 5, septin 2.
      Key Applications
      • Western Blotting
      • Immunofluorescence
      Application NotesImmunofluorescence: Reported by external laboratory using representative lot.
      Biological Information
      ImmunogenHis-tagged recombinant protein corresponding to human Septin-2.
      EpitopeUnknown
      HostRabbit
      SpecificityThis antibody recognizes Septin-2.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteProven to react with human, mouse, and rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SEPT2
      • DIFF6
      • NEDD-5
      • NEDD5
      • Pnutl3
      • hNedd5
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: Required for normal progress through mitosis. Involved in cytokinesis.

      SUBUNIT STRUCTURE: Monomer, and homodimer. Nucleotide binding promotes dimerization. Heterohexamer composed of two heterotrimers containing one copy each of SEPT2, SEPT6 and SEPT7. The asymmetrical heterotrimers associate head-to-head to form a hexameric unit that assembles into filaments.

      SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm › cytoskeleton › spindle. Note: Accumulates near the contractile ring from anaphase through telophase, and finally condenses into the midbody. In interphase and postmitotic cells, localized to fibrous or granular structures, depending on the growth state of the cell By similarity.

      SEQUENCE SIMLARITIES: Belongs to the septin family.
      Molecular Weight 41 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Hek293 cell lysate.

      Western Blot Analysis: 1:1,000 dilution of this antibody detected Septin-2 on 10 µg of Hek293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      07-1813 04053252511707