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MAB3741 Anti-Protein Tyrosine Phosphatase µ Antibody, clone SBK15

This Anti-Protein Tyrosine Phosphatase μ Antibody, clone SBK15 is validated for use in IC, IP, WB for the detection of Protein Tyrosine Phosphatase μ.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Signaling Research Sub-Category: Kinases & Phosphatases Gene Symbol: PTPRM, R-PTP-MU, RPTPU, RPTPM, PTPRL1, R-PTP-mu, hR-PTPu, MGC166994, EC 3.1.3.48 UniProt Number: P28827
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MAB3741
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, Ca, H, M, RICC, IP, WBMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMAB3741
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Protein Tyrosine Phosphatase µ Antibody, clone SBK15
      Alternate Names
      • Receptor-type Protein-tyrosine Phosphatase mu
      • R-PTP-MU
      References
      Product Information
      FormatAscites
      HS Code3002 15 90
      PresentationAscites fluid.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Protein Tyrosine Phosphatase μ Antibody, clone SBK15 is validated for use in IC, IP, WB for the detection of Protein Tyrosine Phosphatase μ.
      Key Applications
      • Immunocytochemistry
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern blot (1:1,000)

      Immunoprecipitation

      Immunostaining (1:200)

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenCorresponds to amino acids 774-1452 of human PTPμ, purified from sf9 cells.
      CloneSBK15
      HostMouse
      SpecificityRecognizes human PTPμ (Protein Tyrosine Phosphatase mu), a Receptor-type protein-tyrosine phosphatase. This antibody recognizes the cytoplasmic domain of PTPμ.
      IsotypeIgG1
      Species Reactivity
      • Bovine
      • Canine
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.
      Gene Symbol
      • PTPRM
      • R-PTP-MU
      • RPTPU
      • RPTPM
      • PTPRL1
      • R-PTP-mu
      • hR-PTPu
      • MGC166994
      • EC 3.1.3.48
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P28827 # Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
      SIZE: 1452 amino acids; 163633 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P28827 ## Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. & Contains 4 fibronectin type-III domains. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 1 MAM domain. & Contains 2 tyrosine-protein phosphatase domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MAB3741 04053252616150

      Documentation

      Anti-Protein Tyrosine Phosphatase µ Antibody, clone SBK15 SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-Protein Tyrosine Phosphatase µ Antibody, clone SBK15 Analysenzertifikate

      TitelChargennummer
      MOUSE ANTI-PROTEIN TYROSINE PHOSPHATASE MU MONOCLONAL ANTIBODY - 2425929 2425929
      MOUSE ANTI-PROTEIN TYROSINE PHOSPHATASE MU - 3509166 3509166
      MOUSE ANTI-PROTEIN TYROSINE PHOSPHATASE MU -2579517 2579517

      Literatur

      ÜbersichtPub Med ID
      Elevated glucocorticoid metabolism in placental tissue from first trimester pregnancies at increased risk of pre-eclampsia.
      S Mukherjee,J L James,B Thilaganathan,G St J Whitley,A E Michael,J E Cartwright
      Placenta  32  2010

      Abstract anzeigen       		21767875 21767875