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MAB2014 Anti-OB-Cadherin Antibody, extracellular domain, clone 16A

Detect OB-Cadherin using this Anti-OB-Cadherin Antibody, extracellular domain, clone 16A validated for use in WB, IC, IH.

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Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: CDH11, CDHOB, CAD11, OB, cadherin-11, OSF-4, OB-cadherin UniProt Number: P55287
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MAB2014
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, ICC, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB2014
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-OB-Cadherin Antibody, extracellular domain, clone 16A
      Alternate Names
      • Cadherin-11
      Background InformationCadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. The progression of carcinomas is associated with the loss of epithelial morphology and a concomitant acquisition of a more mesenchymal phenotype, which is thought to contribute to the invasive and/or metastatic behavior. A putative role for cadherin-11 in these late stages of tumor progression is based on the fact that migration of mesenchymal cells is facilitated when cadherin-11 is highly expressed.
      References
      Product Information
      FormatPurified
      PresentationAffinity purified immuoglobulin. Liquid in PBS containing 0.09% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect OB-Cadherin using this Anti-OB-Cadherin Antibody, extracellular domain, clone 16A validated for use in WB, IC, IH.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesWestern blot: 1:25 - 1:250
      Immunohistochemistry: Frozen tissue sections. 1:25 - 1:50 dilution using avidin-biotinylated horseradish peroxidase complex (ABC) as detection protocol.
      Immunocytochemistry: Methanol and paraformaldehyde-fixed cells
      Optimal working dilutions must be determined by the end user.I/
      Biological Information
      ImmunogenFusion protein corresponding to extracellular domain of human OB-cadherin coupled to GST.
      Epitopeextracellular domain
      Clone16A
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with the extracellular domain of human cadherin-11.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.
      Gene Symbol
      • CDH11
      • CDHOB
      • CAD11
      • OB
      • cadherin-11
      • OSF-4
      • OB-cadherin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P55287 # Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
      SIZE: 796 amino acids; 87965 Da
      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
      SIMILARITY: SwissProt: P55287 ## Contains 5 cadherin domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 4°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MAB2014 04053252398889

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies