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MABC943 Anti-OAS1 Antibody, clone 1D11.1

Anti-OAS1 Antibody, clone 1D11.1 is an antibody against OAS1 for use in Western Blotting.

Anti-OAS1 Antibody, clone 1D11.1 : SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Apoptosis & Cancer Research Sub-Category: RNA Metabolism & Binding Proteins Gene Symbol: OAS1, OIAS, OIASI UniProt Number: P00973
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MABC943
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC943
      DescriptionAnti-OAS1 Antibody, clone 1D11.1
      Alternate Names
      • 2'-5'-oligoadenylate synthase 1
      • (2-5')oligo(A) synthase 1
      • 2-5A synthase 1
      • E18/E16
      • p46/p42 OAS
      Background Information2'-5'-oligoadenylate synthase 1 (EC 2.7.7.84; UniProt P00973; also known as (2-5')oligo(A) synthase 1, 2-5A synthase 1, E18/E16, p46/p42 OAS) is encoded by the OAS1 (also known as OIAS, OIASI) gene (Gene ID 4938) in human. Pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs), including pathogens-derived double-stranded RNA and DNA (dsRNA and dsDNA). The 2'-5' oligoadenylate synthetases (OAS) are interferon-induced cytoplasmic PRRs that recognize virally produced dsRNA and initiate RNA destabilization through activation of RNase L within infected cells. Upon dsRNA binding, OAS enzymes generate the second messenger 2’-5’ oligoadenylate (2-5An; n = 2 to 19), resulting in the dimerization and activation of the latent ribonuclease (RNase L) that degrades host and viral mRNAs. In primates, the OAS family consists of OAS1, OAS2, OAS3, and the catalytically inactive OASL, while 12 rodent Oas genes have been identified, eight of which are OAS1 paralogs.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-OAS1 Antibody, clone 1D11.1 is an antibody against OAS1 for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant internal fragment from the C-terminal half of human OAS1.
      EpitopeInternal (C-terminal half).
      Clone1D11.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 1D11.1 was raised against a recombinant fragment derived from the spliced isoform p46 (E18; Uniprot P00973-1), cross-reactivity toward the p41 (E16; 3-9), p48 (9-2), and p44 spliced isoforms is possible, but has not been determined.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • OAS1
      • OIAS
      • OIASI
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~50 kDa observed. 46.03 kDa (isoform p46; E18), 41.74 kDa (isoform p41; E16; 3-9), 47.41 kDa (isoform p48; 9-2), and 43.94 kDa (isoform p44) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in lysate of IFN gamma-treated HeLa cells.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected OAS1 in 10 µg of lysate from IFN gamma-treated HeLa cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABC943 04055977349443