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AB9698 Anti-Neuron Specific Enolase (NSE) Antibody

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AB9698
500 µL  
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      Übersicht

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MICC, IHC, WBChAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB9698
      ReplacesAB5619
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Neuron Specific Enolase (NSE) Antibody
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified chicken IgY. Two different antibodies were combined to make this product. Liquid in PBS, pH 7.2 with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Neuron Specific Enolase (NSE) Antibody is an antibody against Neuron Specific Enolase (NSE) for use in IC, IH & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunohistochemistry: 1:50-1:100 using 2% paraformaldehyde fixed tissues.
      Immunocytochemistry: 1:50-1:100 using 2% paraformaldehyde fixed cells.
      Western blotting: On mouse brain extracts, blot shows a single band at 47 kDa.
      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptides from human/rat/mouse Neuron Specific Enolase.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostChicken
      SpecificityRecognizes Neuron Specific Enolase (NSE).
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.
      Gene Symbol
      • ENO2
      • NSE
      • Gamma-enolase
      • EC 4.2.1.11
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P09104 # Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
      COFACTOR: Magnesium. Required for catalysis and for stabilizing the dimer.
      SIZE: 434 amino acids; 47269 Da
      SUBUNIT: Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form (By similarity).
      TISSUE SPECIFICITY: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.DEVELOPMENTAL STAGE: During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells.
      SIMILARITY: SwissProt: P09104 ## Belongs to the enolase family.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size500 µL
      Global Trade Item Number
      Bestellnummer GTIN
      AB9698 04053252362828