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MAB5578 Anti-NMDAR2D Antibody

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MAB5578
100 µL  
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      Übersicht

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, RbWBMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMAB5578
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-NMDAR2D Antibody
      Product Information
      FormatAscites
      Control
      • Rat forebrain or cerebellum.
      PresentationLiquid.
      Quality LevelMQ100
      Applications
      ApplicationAnti-NMDAR2D Antibody detects level of NMDAR2D & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:500-1:1,000 on rat brain lysate.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant protein from rat NMDAR2D.
      Clone1G9.39A5
      HostMouse
      SpecificityNMDAR2D, C-terminal. By Western blot the antibody reacts with a weak band at ~145. An additional band at ~75 kDa may be seen depending on sample and antibody concentration used.
      IsotypeIgG2b
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryN-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).
      Gene Symbol
      • GRIN2D
      • EB11
      • Glutamate
      • NR2D
      • NMDAR2D
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O15399 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
      SIZE: 1336 amino acids; 143560 Da
      SUBUNIT: Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      SIMILARITY: SwissProt: O15399 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Global Trade Item Number
      Bestellnummer GTIN
      MAB5578 04053252616570