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07-496-I Anti-Myeloperoxidase Antibody

Anti-Myeloperoxidase Antibody, Cat. No. 07-496-I, is a highly specific rabbit polyclonal antibody that targets Myeloperoxidase and has been tested in Flow Cytometry and Western Blotting.

Anti-Myeloperoxidase Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Gene Symbol: MPO UniProt Number: P05164
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07-496-I
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-496-I
      Replaces07-496
      DescriptionAnti-Myeloperoxidase Antibody
      Alternate Names
      • Myeloperoxidase
      • myeloperoxidase heavy chain
      Background InformationMyeloperoxidase (EC 1.11.2.2; UniProt P05164) is encoded by the MPO gene (Gene ID 4353) in human. Myeloperoxidase/MPO is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a 745 a.a. single chain precursor with a signal peptide sequence (a.a. 1-48), myeloperoxidase is subsequently cleaved into a light chain (a.a.165-278) and a heavy chain (a.a. 279-745). The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. MPO catalyzes hydrogen peroxide-dependent oxidations and the formation of hypochlorous acid that is central to the microbicidal activity of netrophils.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Myeloperoxidase Antibody, Cat. No. 07-496-I, is a highly specific rabbit polyclonal antibody that targets Myeloperoxidase and has been tested in Flow Cytometry and Western Blotting.
      Key Applications
      • Flow Cytometry
      • Western Blotting
      Application NotesFlow Cytometry Analysis: 0.1 µg from a representative lot detected myeloperoxidase immunoreactivity in 4% paraformaldehyde-fixed, 0.2% Triton X-100-permeabilized HL-60 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a sequence within human myeloperoxidase heavy chain region.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThe immunogen sequence is present in the pro-fom and the mature forms of myeloperoxidase (without a.a. 1-48, a.a. 1-154, or a.a. 1-164), as well as the cleaved heavy chain (a.a. 279-745), but not light chain (a.a. 165-278).
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MPO
      Purification MethodAffinity purified.
      UniProt Number
      Molecular Weight~92/60 kDa (glycosylated pro-form/heavy chain) observed. 83.87/73.85/87.25 kDa (isoform H17/H14/H7 pro-form), 78.94/82.32 kDa (isoform H17/H7 with a.a. 1-48 propeptide removed), 66.45/66.45/69.83 kDa (isoform H17/H14/H7 with a.a. 1-154 removed), 65.48/65.48/68.86 kDa (isoform H17/H7 isoform H17/H14/H7 with a.a. 1-164 removed), 52.51 kDa (heavy chain; a.a. 279-745) calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Jurkat cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected myeloperoxidase heavy chain in 10 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      07-496-I 04054839090271

      Documentation

      Anti-Myeloperoxidase Antibody SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-Myeloperoxidase Antibody Analysenzertifikate

      TitelChargennummer
      Anti-Myeloperoxidase - 3261269 3261269
      Anti-Myeloperoxidase - 3318596 3318596
      Anti-Myeloperoxidase - 3475639 3475639
      Anti-Myeloperoxidase - 3794314 3794314
      Anti-Myeloperoxidase - 3874288 3874288
      Anti-Myeloperoxidase - 4059294 4059294
      Anti-Myeloperoxidase - 4123393 4123393
      Anti-Myeloperoxidase - 4185132 4185132
      Anti-Myeloperoxidase -Q2774356 Q2774356
      Anti-Myeloperoxidase Polyclonal Antibody 3162407
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