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MABF1968-25UG Anti-Microglobulin beta2 Antibody, clone BBM.1

This mouse monoclonal Anti-Microglobulin beta2, clone BBM.1 Antibody, Cat. No. MABF1968-25UG is validated for use in Western Blotting and Immunohistochemistry (Paraffin), Inhibition, and Flow Cytometry, for the detection of Microglobulin beta2.

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Research Category: Inflammation & Immunology Gene Symbol: B2M, CDABP0092, HDCMA22P UniProt Number: P61769
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MABF1968-25UG
25 μg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P), Inhibition, FCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF1968-25UG
      DescriptionAnti-Microglobulin beta2 Antibody, clone BBM.1
      Alternate Names
      • B2M
      Background InformationBeta-2-microglobulin (UniProt: P61769) is encoded by the B2M (also known as CDABP0092, HDCMA22P) gene (Gene ID: 567) in human. Beta-2-microglobulin is a component of the class I major histocompatibility complex (MHC) that is involved in the presentation of peptide antigens to the immune system. It is synthesized with a signal peptide of 20 amino acids, which is subsequently cleaved to generate the mature form. It also contains an Ig-like C1 type domain (aa 25-113). Beta-2-microglobulin lacks a transmembrane anchoring domain and is found in secreted as well as in complex. Serum beta-2-microglobulin levels are a reflection of cell turnover and its levels are shown to be elevated in fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. Its levels may be elevated either due to higher rates of synthesis as observed in HIV infection and malignancy or due to impaired renal filtration due to renal insufficiency.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis mouse monoclonal Anti-Microglobulin beta2, clone BBM.1 Antibody, Cat. No. MABF1968-25UG is validated for use in Western Blotting and Immunohistochemistry (Paraffin), Inhibition, and Flow Cytometry, for the detection of Microglobulin beta2.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      • Inhibition
      • Flow Cytometry
      Application NotesImmunohistochemistry Analysis: A representative lot detected Microglobulin beta2 in Immunohistochemistry applications (Josson, S., et. al. (2011). Cancer Res. 71(7):2600-10).

      Inhibition Analysis: A representative lot inhibited Microglobulin beta2 activity (Novoselov, A.V., et. al. (2012). Virus Res. 166(1-2):87-96; Parham, P., et. al. (1983). J Biol Chem. 258(10):6179-86).

      Flow Cytometry Analysis: A representative lot detected Microglobulin beta2 in Flow Cytometry applications (Drukker, M., et. al. (2012). Nat Biotechnol. 30(6):531-42).

      Immunohistochemistry Analysis: A 1:50-1:1,000 dilution from a representative lot detected Microglobulin beta2 in human breast cancer and human tonsil tissues.
      Biological Information
      ImmunogenMOLT-4, a Human acute lymphoblastic leukemia cell line.
      CloneBBM.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone BBM.1 detects Beta-2-microglobulin in human.
      IsotypeIgG2b
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • B2M
      • CDABP0092
      • HDCMA22P
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight14 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in MOLT-4 cell lysates
      Western Blotting Analysis: 0.25 µg/mL of this antibody detected Microglobulin beta2 in 10 µg of MOLT-4 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABF1968-25UG 04054839456176