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AB9448 Anti-Metabotropic Glutamate Receptor 1 Antibody

Detect Metabotropic Glutamate Receptor 1 using this Anti-Metabotropic Glutamate Receptor 1 Antibody validated for use in IH(P).

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Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GRM1, mGluR1, MGLUR1A, GRM1A, mGlu1, MGLUR1, GPRC1A UniProt Number: Q13255
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AB9448
50 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB9448
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Metabotropic Glutamate Receptor 1 Antibody
      Alternate Names
      • mGluR1
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Metabotropic Glutamate Receptor 1 using this Anti-Metabotropic Glutamate Receptor 1 Antibody validated for use in IH(P).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry on paraffin embedded tissue sections.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from the C-terminal domain of human Metabotropic Glutamate Receptor 1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Metabotropic Glutamate Receptor 1 [mGluR1].
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions.
      Gene Symbol
      • GRM1
      • mGluR1
      • MGLUR1A
      • GRM1A
      • mGlu1
      • MGLUR1
      • GPRC1A
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13255 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
      SIZE: 1194 amino acids; 132367 Da
      SUBUNIT: Homodimer; disulfide-linked. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      SIMILARITY: SwissProt: Q13255 ## Belongs to the G-protein coupled receptor 3 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Availability by Geography
      • This product is not available for sale in Japan.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      AB9448 04053252372902

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies