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MAB4147 Anti-MRP1 Antibody, clone MRPm5

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MAB4147
100 µg  
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      Übersicht

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, WB, IHC, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB4147
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-MRP1 Antibody, clone MRPm5
      Product Information
      FormatPurified
      PresentationPurified from tissue culture supernatant, serum-free. Liquid containing 0.7% BSA and 0.1% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationDetect MRP1 using this Anti-MRP1 Antibody, clone MRPm5 validated for use in FC, WB, IH, IH(P).
      Key Applications
      • Flow Cytometry
      • Western Blotting
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      Application NotesWestern blotting

      Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections or paraffin-embedded tissue sections

      Flow Cytometry

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenBacterial fusion protein of MRP1 containing amino acids 986-1204 of the protein.
      CloneMRPm5
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody reacts with an internal epitope of MRP1, a 180-195 kDa transmembrane transporter protein overexpressed in various human non-P-glycoprotein MDR tumor cell lines. The antibody does not cross-react with the human MDR1 and MDR3 gene products.
      IsotypeIgG2a
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
      Gene Symbol
      • ABCC1
      • 4transporter)
      • ABC29
      • GS-X
      • ABCC
      • MRP1
      • DKFZp781G125
      • MRP
      • DKFZp686N04233
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P33527 # May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Confers resistance to anticancer drugs. Transports LTC4. May protect milk against xenobiotics (By similarity).
      SIZE: 1531 amino acids; 171561 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Lung, testis and peripheral blood mononuclear cells.
      SIMILARITY: SwissProt: P33527 ## Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze-thaw cycles.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Bestellnummer GTIN
      MAB4147 04053252578458