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AB6020 Anti-MAP4 Antibody

This Anti-MAP4 Antibody is validated for use in WB, IC for the detection of MAP4.

Anti-MAP4 Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Cell Structure Research Sub-Category: Cytoskeleton Gene Symbol: MAP4, MAP-4 UniProt Number: P27816
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AB6020
50 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, Eq, Ca, BWB, ICCRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB6020
      DescriptionAnti-MAP4 Antibody
      Alternate Names
      • microtubule-associated protein 4
      • cdc kinase
      • MAP-4
      Background InformationMicrotubule-associated protein 4 (MAP4) is a ubiquitous non-neuronal microtubule-associated protein. This protein binds, polymerizes, and stabilizes microtubules and is thought to regulate microtubule dynamics during the cell cycle. p34cdc2 kinase phosphorylation of MAP4 appears to regulate the control of microtubule reorganization at mitosis (Ookata, 1997).
      References
      Product Information
      FormatPurified
      Control
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-MAP4 Antibody is validated for use in WB, IC for the detection of MAP4.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern blot (SNAP ID) Analysis: 0.5 µg/mL from a previous lot detected MAP4 in 10 µg of HeLa cell lysate.

      Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected MAP4 in HeLa, NIH/3T3, and A431 cells.
      Biological Information
      ImmunogenKLH-conjugated peptide corresponding to the C-terminus of human MAP4.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityAntibody recognizes the C-terminus of MAP4.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Horse
      • Canine
      • Bovine
      Species Reactivity NoteDemonstrated to react with human, mouse, and rat. Predicted to react with equine, canine, and bovine based upon 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
      Gene Symbol
      • MAP4
      • MAP-4
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

      SUBUNIT STRUCTURE: Interacts with SEPT2; this interaction impedes tubulin-binding.

      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.

      SEQUENCE SIMILARITIES: Contains 4 Tau/MAP repeats.
      Molecular Weight~ 220 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western blot in HeLa cell lysate.

      Western blot Analysis: 0.05 µg/mL of this antibody detected MAP4 in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      AB6020 04053252515149

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies