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MABE421 Anti-Lymphoid-specific helicase (SMARCA6) Antibody, clone 2G7.1

This Anti-Lymphoid-specific helicase (SMARCA6) Antibody, clone 2G7.1 is validated for use in western blotting & IHC for the detection of Lymphoid-specific helicase (SMARCA6).

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Research Category: Epigenetics & Nuclear Function Research Sub-Category: Signaling Neuroscience Gene Symbol: HELLS, PASG, SMARCA6 UniProt Number: Q9NRZ9
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MABE421
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE421
      DescriptionAnti-Lymphoid-specific helicase (SMARCA6) Antibody, clone 2G7.1
      Alternate Names
      • Lymphoid-specific helicase
      • Proliferation-associated SNF2-like protein
      • SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6
      Background InformationA member of the SNF2 family of chromatin remodeling proteins, Lymphoid-specific helicase (HELLS, also known as Lsh) assumes various roles in normal development, survival, de novo or maintenance DNA methylation, gene silencing, and heterochromatin formation and organization. It is shown to serve as cancer progression marker in conjunction with CEP55 and FOXM1 for the detection of head and neck squamous cell carcinoma (HNSCC). It is also reported that expression of Lsh is crucial for meiotic progression in mouse spermatocytes. Lsh is shown to directly associate with the 5' DMR of the Cdkn1c promoter, and thereby regulate its gene expression. Additionally, Lsh is reported as a regulator of repressive chromatin at retrotransposons, and is demonstrated to mediate the silencing of stem cell-specific genes such as Oct4.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Lymphoid-specific helicase (SMARCA6) Antibody, clone 2G7.1 is validated for use in western blotting & IHC for the detection of Lymphoid-specific helicase (SMARCA6).
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Lymphoid-specific helicase (SMARCA6) in human placenta tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Lymphoid-specific helicase (SMARCA6).
      Clone2G7.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HELLS
      • PASG
      • SMARCA6
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~97 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human thymus tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Lymphoid-specific helicase (SMARCA6) in 10 µg of human thymus tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABE421 04053252966088