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MAB1613 Anti-Kinesin Antibody, heavy chain, non-neuronal KHC, clone H1

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MAB1613
100 µg  
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      Übersicht

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, RELISA, IP, RIA, WB, ICC, IHC, FUNCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB1613
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Kinesin Antibody, heavy chain, non-neuronal KHC, clone H1
      Product Information
      FormatPurified
      PresentationLiquid in 0.02 M Phosphate buffer, 0.25 M NaCl.pH 7.6 with 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Kinesin Antibody, heavy chain, non-neuronal KHC, clone H1 detects level of Kinesin & has been published & validated for use in ELISA, IP, RIA, WB, IC, IH.
      Key Applications
      • ELISA
      • Immunoprecipitation
      • Radioimmunoassay
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      • Affects Function
      Application NotesImmunohistochemistry on paraformaldehyde fixed tissue. Also works for EM.

      Immunocytochemistry: paraformaldehyde fixed cells; 5-10' RT, freshly made 4% PFA; permeabilize with 0.1-.2% triton X-100 in 3% normal serum blocking buffer

      Immunoblotting: recognizes 124kDa KHC from non-neuronal samples.

      Immunoprecipitation

      Inhibition of kinesin mediated transport

      EIA/RIA

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenBovine brain kinesin.
      Epitopeheavy chain, non-neuronal KHC
      CloneH1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with the major form of heavy chain of non-neuronal KHC near the N-terminus.
      IsotypeIgG1
      Species Reactivity
      • Bovine
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KIF5B
      • UKHC
      • KINH
      • KNS1
      • KNS
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P33176 # Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity).
      SIZE: 963 amino acids; 109685 Da
      SUBUNIT: Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 (By similarity). Interacts with SYBU.
      SUBCELLULAR LOCATION: Note=Uniformly distributed between soma and neurites in hippocampal neurons (By similarity).
      DOMAIN: SwissProt: P33176 Composed of three structural domains: a large globular N- terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
      SIMILARITY: Belongs to the kinesin-like protein family. Kinesin subfamily. & Contains 1 kinesin-motor domain.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Bestellnummer GTIN
      MAB1613 04053252661358