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AB9880 Anti-Huntingtin-Interacting Protein (HIP1) Antibody

Anti-Huntingtin-Interacting Protein (HIP1) Antibody detects level of Huntingtin-Interacting Protein (HIP1) & has been published & validated for use in WB.

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Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases, Synapse & Synaptic Biology Gene Symbol: HIP1, HIP-I, MGC126506, ILWEQ UniProt Number: O00291
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AB9880
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB9880
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Huntingtin-Interacting Protein (HIP1) Antibody
      Alternate Names
      • HIP1
      References
      Product Information
      FormatPurified
      PresentationLiquid
      Quality LevelMQ100
      Applications
      ApplicationAnti-Huntingtin-Interacting Protein (HIP1) Antibody detects level of Huntingtin-Interacting Protein (HIP1) & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:500-1:1,000 on P2 microsomal fraction from embryonic rat brain.





      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide
      HostRabbit
      SpecificityHuntingtin-interacting protein 1 (HIP1). By Western blot the antibody recognizes a band at ~116 kDa on P2 microsomal fraction from embryonic rat brain.
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. An alternative splice variant of this gene has been described but its full length sequence has not been determined.
      Gene Symbol
      • HIP1
      • HIP-I
      • MGC126506
      • ILWEQ
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O00291 # May play a functional role in the cell filament networks.
      SIZE: 1030 amino acids; 115442 Da
      SUBUNIT: Binds huntingtin. This interaction is restricted to the brain. Binds to Hippi.
      SUBCELLULAR LOCATION: Intracytoplasmic membrane.
      TISSUE SPECIFICITY: Ubiquitously expressed with the highest level in brain.
      SIMILARITY: SwissProt: O00291 ## Belongs to the SLA2 family. & Contains 1 ENTH (epsin N-terminal homology) domain. & Contains 1 I/LWEQ domain.
      MISCELLANEOUS: The affinity of the huntingtin protein-HIP1 interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.
      Molecular Weight116 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      AB9880 04053252729522