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AB5401-25UL Anti-Growth Associated Protein 43 Antibody, phosphoSer 41

This Anti-Growth Associated Protein 43 Antibody, phosphoSer 41 is validated for use in WB for the detection of Growth Associated Protein 43.

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Research Category: Neuroscience Research Sub-Category: Neuroregenerative Medicine, Signaling Neuroscience Gene Symbol: GAP43, PP46, Neuromodulin, B-50, neuromodulin UniProt Number: P17677
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AB5401-25UL
25 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5401-25UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Growth Associated Protein 43 Antibody, phosphoSer 41
      Alternate Names
      • GAP-43
      • Neuromodulin
      Background InformationGAP-43, a common marker of differentiating neurons, is expressed at elevated levels by developing or regenerating neurons during axon growth. While GAP-43 is an integral membrane protein associated with the cytoplasmic surface of axonal growth cones (and synapses), it is absent from dendritic growth cones. In adult brain, GAP-43 is found in high concentration in presynaptic areas where memory formation is thought to occur, such as frontal cortex, limbic system and hippocampus. Phosphorylation of GAP-43 by PKC (at Ser41 on human, mouse, rat, and bovine GAP-43 or Ser42 on chicken and Xenopus GAP-43) is specifically correlated with certain forms of synaptic plasticity.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Synthetic peptide corresponding to amino acids surrounding the phosphoSer41 of rat GAP-43.
      PresentationAffinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl with 100 mg/mL BSA and 50% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Growth Associated Protein 43 Antibody, phosphoSer 41 is validated for use in WB for the detection of Growth Associated Protein 43.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:1,000 (43KDa band).

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acids surrounding the phosphoSer41 of rat GAP-43. This is the site phosphorylated by protein kinase C.
      EpitopephosphoSer 41
      HostRabbit
      SpecificityGAP-43 phosphoSer41. The labeling of the GAP-43 protein (~43kDa) in Western blots of rat brain is blocked by the phosphopeptide but not by the dephosphopeptide. In some tissues the antibody may recognize a lower molecular weight band. This band is also detected by a pan GAP-43 antibody.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This encoded protein is considered a crucial component of an effective regenerative response in the nervous system.
      Gene Symbol
      • GAP43
      • PP46
      • Neuromodulin
      • B-50
      • neuromodulin
      Modifications
      • Phosphorylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17677 # This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons.
      SIZE: 238 amino acids; 24803 Da
      SUBUNIT: Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.
      PTM: Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.
      SIMILARITY: SwissProt: P17677 ## Belongs to the neuromodulin family. & Contains 1 IQ domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
      Packaging Information
      Material Size25 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      AB5401-25UL 04053252730597

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      Alternative Packsize

      Bestellnummer Beschreibung  
      AB5401 Anti-Growth Associated Protein 43 Antibody, phosphoSer 41 Preis & Verfügbarkeit

      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies