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MABN698 Anti-FABP2 Antibody, clone 9A9B7B3

Detect Fatty Acid Binding Protein using this mouse monoclonal antibody, Anti-FABP2 Antibody, clone 9A9B7B3 validated for use in western blotting, Immunofluorescence, IHC & Flow Cytometry.

Anti-FABP2 Antibody, clone 9A9B7B3: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: FABPI, FABP2 UniProt Number: P12104
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MABN698
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IF, IHC, FCMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMABN698
      ReplacesMABS390; MABS401
      DescriptionAnti-FABP2 Antibody, clone 9A9B7B3
      Alternate Names
      • Fatty acid-binding protein, intestinal
      • Fatty acid-binding protein 2
      • Intestinal-type fatty acid-binding protein
      • I-FABP
      Background InformationFatty acid-binding protein 2, (FABP2) is a fatty acid-binding protein produced by the intestinal tissues of the small intestine and participates in the transport and intracellular internalization and metabolism of fatty acids in the gut. Its expression is localized to the small intestine, especially within the cellular epithelial cells of the jejunum, with much lower levels in the large intestine. Its expression is confined to the cytoplasm and induced by growth factors such as EGF. FABP2 is also known as FABPI or I-FABP. Because of its role in fatty acid uptake and lipid homeostasis, mutations or polymorphisms affecting the function of FABP2 in fatty acid metabolism have been a source of recent research. In particular, an amino acid substitution known as A54T where the G to A polymorphism of codon 54 of the FABP2 gene results in the substation of a Thr in the mutated form instead of an Ala in the normal form. This Thr-codon 54 mutation demonstrates an increased affinity for long-chain fatty acids and is strongly associated with factors associated with metabolic syndrome disease, including insulin resistance, enhanced fatty acid oxidation, elevated triglycerides and type 2 diabetes. Furthermore, FABPs and in particular , FABP2, play an increasingly important role in controlling the lipid signaling cascade and FABP2 is being studied as key regulatory factor of lipid signaling under normal and pathological conditions. EMD-Millipore’s anti-FABP2 mouse monoclonal antibody, clone 9A9B7B3, has been tested in western blot, paraffin embedded immunohistochemical, and flow cytometry studies using human tissues and cell lines. The clone also reacts with FABP2 from NIH-3T3-L1 mouse cells lines by immunocytochemistry.
      References
      Product Information
      FormatAscites
      Control
      • Human small intestine tissue lysate
      PresentationMouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Fatty Acid Binding Protein using this mouse monoclonal antibody, Anti-FABP2 Antibody, clone 9A9B7B3 validated for use in western blotting, Immunofluorescence, IHC & Flow Cytometry.
      Key Applications
      • Western Blotting
      • Immunofluorescence
      • Immunohistochemistry
      • Flow Cytometry
      Application NotesImmunofluorescence Analysis: A 1:200-1,000 dilution from a representative lot detected FABP2 in 3T3-L1 cells.

      Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected FABP2 in human small Intestine tissues.

      Flow Cytometry Analysis: A 1:200-400 dilution from a representative lot detected FABP2 in LOVO cells.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPurified recombinant fragment of human FABP2 expressed in E. Coli.
      Clone9A9B7B3
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • FABPI
      • FABP2
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~15 kDa observed.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human small intestine tissue lysate.

      Western Blotting Analysis: A 1:2,000 dilution of this antibody detected FABP2 in human small intestine tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABN698 04053252914386