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MAB8121 Anti-Cytomegalovirus Antibody, blend, clone 8B1.2, 1G5.2, and 2D4.2

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MAB8121
100 µg  
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      Übersicht

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIF, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB8121
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Cytomegalovirus Antibody, blend, clone 8B1.2, 1G5.2, and 2D4.2
      Alternate Names
      • CMV
      Product Information
      FormatPurified
      Presentation0.02 M PB, 0.25M NaCl, PH 7.6 with 0.1% Sodium Azide.
      Quality LevelMQ300
      Applications
      ApplicationThis Anti-Cytomegalovirus Antibody, blend, clone 8B1.2, 1G5.2 & 2D4.2 is validated for use in IF, IH for the detection of Cytomegalovirus.
      Key Applications
      • Immunofluorescence
      • Immunohistochemistry
      Application NotesImmunohistochemistry

      Immunofluorescence

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenMRC-5 infected cells with ATCC VR538 and AD169, ultrasonicated, screened by plate reduction neutralization tests.
      Epitopeblend
      Clone8B1.2, 1G5.2, and 2D4.2
      HostMouse
      SpecificityReacts with Immediate early, early, and late antigen preparations. Can detect CMV infection within 2 hours post-infection exhibiting a nuclear staining which reaches peak intensity between 48 and 96 hours. This antigen is persisting and can be detected during the complete CMV infection cycle. Staining of CMV structural antigens becomes apparent at about 48 hours. Extra-nuclear staining is first seen in the region of the golgi apparatus followed subsequently by staining of viral proteins and particles in the cytoplasm.

      With CMV the antigens expressed at different times are listed as:



      Immediate Early (alpha gene expression): those antigens expressed at 3-12 hrs post-infection generally involved in Transcription such as 72kD major phosphoprotein and a few other other antigens at 60 - 80kD.

      Early Antigen (beta genes) a.k.a. Delayed Early or Intermediate Early: expressed at 12-24hrs post-infection. Generally enzymes and one virion structural gene preceding viral DNA synthesis.

      Late Antigen (gamma genes): expressed at 36-48hrs post-infection. Generally structural proteins. Major protein = 55kD
      IsotypeIgG2a
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at +2-8C in convenient aliquots for up to 6 months. Do not freeze.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Bestellnummer GTIN
      MAB8121 04053252612206