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AB15500 Anti-Calcium Transporter 1 Antibody

Anti-Calcium Transporter 1 Antibody detects level of Calcium Transporter 1 & has been published & validated for use in ELISA & WB.

Anti-Calcium Transporter 1 Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: TRPV6, TrpV6, ABP/ZF, CaT1, CaT-like, CATL, CAT1, ECAC2, HSA277909, ZFAB, CaT-L, ECaC2, LP6728 UniProt Number: Q9H1D0
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AB15500
50 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RELISA, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB15500
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Calcium Transporter 1 Antibody
      Alternate Names
      • CaT-1
      • ECAC2
      Background InformationCaT-1 (rat/mouse 727 aa; human 725 aa, chromosome 7q33-q34; ~85 kDa) is also known as ECAC2, CAT-like (CATL) or TRPV6 (transient receptor potential cation channel, subfamily V, member 6) contains a cytoplasmic N-terminus, 6 ankyrin repeat domains, 6 transmembrane domains, an extracellular pore region between TM5-6, and cytoplasmic C-terminus. CaT-1 shows 75% sequence identity to epithelial Ca++ channel (ECaC) protein from rabbit kidney. In rat, CaT-1 transcript (3-Kb) is expressed in duodenum, proximal jejunum cecum and colon but not in kidney; whereas ECaC in rabbit is expressed in apical cell membranes in distal part of nephron (kidney), duodenum, jejunum and placenta.
      References
      Product Information
      FormatAffinity Purified
      PresentationLiquid in PBS with 0.1% BSA.
      Quality LevelMQ300
      Applications
      ApplicationAnti-Calcium Transporter 1 Antibody detects level of Calcium Transporter 1 & has been published & validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-10 µg/mL using ECL. The expected size of CaT-1 is ~83 kDa. However, posttranslational modification may alter its size depending upon the species and cell type.
      Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 µg/mL
      ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well.
      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide near the C-terminus of rat CaT-1.
      HostRabbit
      SpecificityCalcium transporter 1 (CaT-1, ECAC2). The immunogen sequence has no significant homology with CaT-2 or other proteins.
      Species Reactivity
      • Rat
      Species Reactivity NoteOther species have not yet been tested. The immunogen sequence is 100% conserved in mouse, 88% in humans and 94% in Cat-1/htrp8A and htrp8b proteins.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCalcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH; MIM 168450), or calcitonin (CALCA; MIM 114130).[supplied by OMIM]
      Gene Symbol
      • TRPV6
      • TrpV6
      • ABP/ZF
      • CaT1
      • CaT-like
      • CATL
      • CAT1
      • ECAC2
      • HSA277909
      • ZFAB
      • CaT-L
      • ECaC2
      • LP6728
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9H1D0 # Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
      SIZE: 725 amino acids; 83210 Da
      SUBUNIT: Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY (By similarity). Interacts with calmodulin.
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
      TISSUE SPECIFICITY: Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia.
      PTM: Glycosylated (By similarity). & Phosphorylation by PRKCA at the calmodulin binding site delays channel inactivation.
      SIMILARITY: SwissProt: Q9H1D0 ## Belongs to the transient receptor family. TrpV subfamily. & Contains 5 ANK repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      AB15500 04053252468445

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      Kategorien

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