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07-068-I Anti-Calcineurin A/PP2B catalytic unit Antibody

This Anti-Calcineurin A/PP2B catalytic unit antibody is validated for use in western blotting & IP for the detection of Calcineurin A/PP2B catalytic unit.

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Research Category: Signaling Research Sub-Category: Metabolic Hormones & Receptors Gene Symbol: Ppp3cb UniProt Number: P20651
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07-068-I
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IPRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-068-I
      Replaces07-068
      DescriptionAnti-Calcineurin A/PP2B catalytic unit Antibody
      Alternate Names
      • Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
      • CAM-PRP catalytic subunit
      • Calmodulin-dependent calcineurin A subunit beta isoform
      Background InformationCalcineurin/PP2B Aβ, also known as Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, and encoded by the gene PPP3CB/CALNA2/CALNB/CNA2, is a calcium dependent, calmodulin stimulated catalytic subunit protein phosphatase critical in the function of Calcineurin an important phosphatase governing immune responses such as T cell activation and the T cell immune response. Calcineurin is a heterodimeric protein consisting of a catalytic subunit Calcineurin A, which contains an active site dinuclear metal center, and a tightly associated, myristoylated, Ca(2+)-binding subunit, Calcineurin B. Calcineurin/PP2B Aβ is the beta isoform of the catalytic active site of the subunit A of Calcineurin. Calcineurin also plays pivotal roles in signaling transduction cascades in a variety of other immune cells as well as non-immune cells like myocytes and neurons.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Calcineurin A/PP2B catalytic unit antibody is validated for use in western blotting & IP for the detection of Calcineurin A/PP2B catalytic unit.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis: 5 µg from a representative lot immunoprecipitated Calcineurin A/PP2B catalytic unit in 500 µg of mouse brain tissue lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to rat Calcineurin A/PP2B catalytic unit near the C-terminus.
      EpitopeNear C-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Ppp3cb
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~57 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human brain tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Calcineurin A/PP2B catalytic unit in 10 µg of human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      07-068-I 04053252956768