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07-735 Anti-CENP-B Antibody

Anti-CENP-B Antibody is a Rabbit Polyclonal Antibody for detection of CENP-B also known as Centromere autoantigen B & has been tested in WB.

Anti-CENP-B Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Cell Cycle, DNA Replication & Repair Gene Symbol: CENPB, CENP-B UniProt Number: P07199
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07-735
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-735
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-CENP-B Antibody
      References
      Product Information
      FormatPurified
      Quality LevelMQ100
      Applications
      ApplicationAnti-CENP-B Antibody is a Rabbit Polyclonal Antibody for detection of CENP-B also known as Centromere autoantigen B & has been tested in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenBeta galactosidase fusion protein of human CENP-B.
      HostRabbit
      SpecificityBeta galactosidase fusion protein of human CENP-B.
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
      Gene Symbol
      • CENPB
      • CENP-B
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P07199 # Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.
      SIZE: 599 amino acids; 65171 Da
      SUBUNIT: Homodimer.
      SUBCELLULAR LOCATION: Nucleus.
      SIMILARITY: SwissProt: P07199 ## Contains 1 HTH CENPB-type DNA-binding domain. & Contains 1 HTH psq-type DNA-binding domain.
      Molecular Weight80kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      07-735 04053252470059

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies