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MABF1542 Anti-CD8a (Mouse), FITC, clone 53-6.7 Antibody

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MABF1542
100 μg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFCRFITCMonoclonal Antibody
      Description
      Catalogue NumberMABF1542
      DescriptionAnti-CD8a (Mouse), FITC, clone 53-6.7 Antibody
      Alternate Names
      • T-cell surface glycoprotein CD8 alpha chain
      • T-cell surface glycoprotein Lyt-2
      • CD8a
      • CD8a
      Background InformationThe 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.The 53-6.7 antibody is widely used as a phenotypic marker for mouse CD8a expression on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.
      References
      Product Information
      FormatFITC
      PresentationPurified Rat monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
      Quality LevelMQ100
      Applications
      ApplicationThis rat monoclonal Anti-CD8a Antibody (Mouse), FITC, clone 53-6.7, Cat. No. MABF1542 is validated for use in Flow Cytometry, for the detection of CD8a.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenImmunogen information for this antibody is proprietary information.
      Clone53-6.7
      ConcentrationPlease refer to lot specific datasheet.
      HostRat
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • CD8a
      Purification MethodPurified by size-exclusion chromatography
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThis monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

      Flow Cytometry Analysis: 0.5 μg from a representative lot detected CD8a in one million C57Bl/6 splenocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABF1542 04055977293395

      Documentation

      Anti-CD8a (Mouse), FITC, clone 53-6.7 Antibody SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-CD8a (Mouse), FITC, clone 53-6.7 Antibody Analysenzertifikate

      TitelChargennummer
      Anti-CD8a (Mouse), FITC, -QVP1505126 QVP1505126
      Anti-CD8a (Mouse), FITC, clone 53-6.7 - VP2202173 VP2202173
      Anti-CD8a (Mouse), FITC, clone 53-6.7 - VP2405012 VP2405012
      Anti-CD8a (Mouse), FITC, clone 53-6.7 Monoclonal Antibody VP1703311
      Anti-CD8a (Mouse), FITC, clone 53-6.7, -VP1801242 VP1801242

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