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MABS2074-100UG Anti-CD265/RANK Antibody, clone 8G1-24

Anti-CD265/RANK, clone 8G1-24, Cat. No. MABS2074, is a mouse monoclonal antibody that detects RANK (CD265) and is tested for use in Flow Cytometry and Western Blotting.

MABS2074-100UG
100 μg  
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      Übersicht

      Replacement Information
      Description
      Catalogue NumberMABS2074-100UG
      DescriptionAnti-CD265/RANK Antibody, clone 8G1-24
      Alternate Names
      • Tumor necrosis factor receptor superfamily member 11A
      • Osteoclast differentiation factor receptor
      • ODFR
      • Receptor activator of NF-KB
      • CD265
      Background InformationTumor necrosis factor receptor superfamily member 11A (UniProt: Q9Y6Q6; also known as Osteoclast differentiation factor receptor, ODFR, Receptor activator of NF-KB, CD265) is encoded by the TNFRSF11A (also known as RANK) gene (Gene ID: 8792) in human. CD265 is a single-pass type I membrane protein that serves a receptor for TNFSF11/RANKL and is considered to be essential for RANKL-mediated osteoclastogenesis. It has ubiquitous expression, but high expression is observed in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is also expressed on dendritic cells and facilitates immune signaling. It interacts with various TRAF family proteins and induces the activation of NF-kappa B and MAPK8/JNK. It is shown to bind to the clefts between the subunits of the TNFSF11/ RANKL ligand trimer to form a heterohexamer. CD265 is synthesized with a signal peptide (aa 1-29), which is subsequently cleaved off to generate the mature form that contains an extracellular domain (aa 30-212), a short transmembrane domain (aa 213-233), and a cytoplasmic domain (aa 234-616). It also contains four extracellular cysteine-rich pseudorepeats.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-CD265/RANK, clone 8G1-24, Cat. No. MABS2074, is a mouse monoclonal antibody that detects RANK (CD265) and is tested for use in Flow Cytometry and Western Blotting.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 1 µg from a representative lot detected CD265/RANK in one million K562 cells.
      Biological Information
      ImmunogenExtracellular domain of human RANK (CD265).
      Epitopeextracellular domain
      Clone8G1-24
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 8G1-24 is a mouse monoclonal antibody that detects human RANK(CD2 65). It targets an epitope within the extracellular domain.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TNFRSF11A
      • RANK
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight66.03 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in K562 cell lysates.

      Western Blotting Analysis: 1 µg/mL of this antibody detected CD265/RANK in K562 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABS2074-100UG 04061841038849