124018 Sigma-AldrichAkt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a cell-permeable, reversible & selective inhibitor of Akt1/Akt2 (IC50 = 58 nM and 210 nM for Akt1 & Akt2, respectively),
More>> Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a cell-permeable, reversible & selective inhibitor of Akt1/Akt2 (IC50 = 58 nM and 210 nM for Akt1 & Akt2, respectively), Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Akti-1/2
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 612847-09-3 | C₃₄H₂₉N₇O |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 124018-1MG |
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Kst.-Ampulle | 1 mg |
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| 124018-5MG |
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Glasflasche | 5 mg |
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| Description | |
|---|---|
| Overview | A cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 µM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50 µM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo. A 10 mM (1 mg/181 µl) solution of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124017) in DMSO is also available. |
| Catalogue Number | 124018 |
| Brand Family | Calbiochem® |
| Synonyms | 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Akti-1/2 |
| Product Information | |
|---|---|
| CAS number | 612847-09-3 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₃₄H₂₉N₇O |
| Chemical formula | C₃₄H₂₉N₇O |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ200 |
| Biological Information | |
|---|---|
| Primary Target | Akt1, Akt2, Akt3 |
| Primary Target IC<sub>50</sub> | 58 nM, 210 nM, 2.12 µM against Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 124018-1MG | 07790788048006 |
| 124018-5MG | 04055977205718 |
Documentation
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem SDB
| Titel |
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Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - CAS 612847-09-3 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 124018 |
Literatur
| Übersicht |
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| Calleja, V., et al. 2009. PLoS Biol. 7, e17. Logie, L., et al. 2007. Diabetes 56, 228. Barnett, S.F., et al. 2005. Biochem. J. 385, 399. DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271. Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905. Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761. |
Broschüre
| Titel |
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| Akt |
Posters
| Titel |
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| Human Kinome & InhibitorSelect™ Libraries |