Millipore Sigma Vibrant Logo

121767 AG 1024 - CAS 65678-07-1 - Calbiochem

A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity.

AG 1024 - CAS 65678-07-1 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 3-Bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile

Primary Target: IGF-1
View Products on Sigmaaldrich.com
121767
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
65678-07-1C₁₄H₁₃BrN₂O

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
121767-1MG
Verfügbarkeit wird abgerufen...
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      		 Kst.-Ampulle 1 mg
      Preis wird abgerufen...
      Preis nicht abrufbar
      Die Mindestmenge muss ein Vielfaches sein von
      Maximum Quantity is
      Bei Bestätigung Weitere Informationen
      Sie haben () gespart
       
      —
      Bitte erfragen
      		 —
      Description
      OverviewA cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.
      Catalogue Number121767
      Brand Family Calbiochem®
      Synonyms3-Bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile
      References
      ReferencesWen, B., et al. 2001. Br. J. Cancer 85, 2017.
      Parrizas, M., et al. 1997. Endocrinology 138, 1427.
      Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
      Product Information
      CAS number65678-07-1
      ATP CompetitiveN
      FormOff-white to yellow solid
      Hill FormulaC₁₄H₁₃BrN₂O
      Chemical formulaC₁₄H₁₃BrN₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIGF-1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      121767-1MG 04055977223491

      Documentation

      AG 1024 - CAS 65678-07-1 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      AG 1024 - CAS 65678-07-1 - Calbiochem Analysenzertifikate

      TitelChargennummer
      121767

      Literatur

      Übersicht
      Wen, B., et al. 2001. Br. J. Cancer 85, 2017.
      Parrizas, M., et al. 1997. Endocrinology 138, 1427.
      Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms3-Bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile
      DescriptionA cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases with significantly lower IC50 values for IGF-1 than for insulin receptors. Induces apoptosis by downregulating the expression of phospho-Akt1 and Bcl-2; and increasing the expression of Bax, p53 and p21. Reported to enhance the radiosensitivity of human breast cancer cells.
      FormOff-white to yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number65678-07-1
      Chemical formulaC₁₄H₁₃BrN₂O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesWen, B., et al. 2001. Br. J. Cancer 85, 2017.
      Parrizas, M., et al. 1997. Endocrinology 138, 1427.
      Ohmichi, M., et al. 1993. Biochemistry 32, 4650.