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AG533 ADAM 10, control peptide for AB19026

ADAM 10, control peptide for AB19026: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Gene Symbol: ADAM10, CDw156, CD156c, HsT18717, kuzbanian, kuz, MADM, KUZ, EC 3.4.24.81 UniProt Number: O14672
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AG533
50 µg  
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      Übersicht

      Replacement Information
      Description
      Catalogue NumberAG533
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionADAM 10, control peptide for AB19026
      OverviewControl peptide for Chemicon Cat. No. AB19026 (Rabbit anti-ADAM10). Peptide corresponds to amino acids 732-748 near the C-terminus.
      References
      Product Information
      PresentationLiquid in PBS, pH 7.2, containing 0.1% BSA and 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      Key Applications
      • Peptide Inhibition Assay
      Application NotesBlocking: Use 1 μg control peptide per 1 μg antibody . Control peptide, because of it's small size (2-3 kDa), is not recommended for Western.

      Optimal working dilutions must be determined by end user.
      Biological Information
      Concentration0.2 mg/mL
      SourceSynthetic peptide
      Entrez Gene Number
      Entrez Gene SummaryMembers of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin.
      Gene Symbol
      • ADAM10
      • CDw156
      • CD156c
      • HsT18717
      • kuzbanian
      • kuz
      • MADM
      • KUZ
      • EC 3.4.24.81
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O14672 # Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity).
      COFACTOR: Binds 1 zinc ion (By similarity).
      SIZE: 748 amino acids; 84142 Da
      SUBUNIT: Interacts with ephrin-A2 (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Intracytoplasmic membrane; Single-pass type I membrane protein. Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.
      TISSUE SPECIFICITY: Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
      DOMAIN: SwissProt: O14672 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
      PTM: The precursor is cleaved by a furin endopeptidase (By similarity).
      SIMILARITY: Contains 1 disintegrin domain. & Contains 1 peptidase M12B domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      AG533 04053252469329

      Documentation

      ADAM 10, control peptide for AB19026 SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      ADAM 10, control peptide for AB19026 Analysenzertifikate

      TitelChargennummer
      HUMAN ADAM10 CONTROL PEPTIDE FOR AB19026 - 2376017 2376017
      HUMAN ADAM10 CONTROL PEPTIDE FOR AB19026 2969350
      HUMAN ADAM10 CONTROL PEPTIDE FOR AB19026 - 2186339 2186339
      HUMAN ADAM10 CONTROL PEPTIDE FOR AB19026 - 2224431 2224431
      HUMAN ADAM10 CONTROL PEPTIDE FOR AB19026 - 2272129 2272129
      HUMAN ADAM10 CONTROL PEPTIDE FOR AB19026 - 2283862 2283862
      HUMAN ADAM10 CONTROL PEPTIDE FOR AB19026 - 2352400 2352400
      HUMAN ADAM10 CONTROL PEPTIDE FOR AB19026 - 3829502 3829502

      Literatur

      ÜbersichtPub Med ID
      Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteinases
      Rosendahl, M.S.
      J. Biol. Chem., 272:24588-24593 (1997)  1997

      		9305925 9305925